Upregulation of GTPBP4 Promotes the Proliferation of Liver Cancer Cells.
Upregulation of GTPBP4 Promotes the Proliferation of Liver Cancer Cells.
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DOI：
10.1155/2021/1049104
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发表时间：
2021
影响因子：
--
通讯作者：
Zhang Z
中科院分区：
文献类型：
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作者：
Chen J;Zhang J;Zhang Z
GTPBP4在肝癌患者中表达上调(P<；0.01)，但在不同临床病理分期患者中的表达差异无统计学意义。GTPBP4的表达随淋巴结转移的增加而增加(P<；0.01)。GTPBP4表达上调的肝癌患者总生存率较低(P=0.02)。GTPBP4与NIFK、WDR12和RPF2等基因密切相关，这些基因参与了GTP结合和rRNA加工等生命过程。GTPBP4的表达上调促进了小鼠肝癌细胞的增殖，促进了肿瘤的生长，而GTPBP4的表达下调抑制了肝癌细胞的增殖，抑制了肿瘤的生长。GTPBP4在肝癌患者中表达上调，影响患者的总体生存率。GTPBP4表达上调促进了肝癌细胞的增殖和肿瘤的生长。
The GTPBP4 has upregulated expression in liver cancer patients (P < 0.01), but there was no difference in its expression in patients with different clinicopathological stages. The expression of GTPBP4 increased with the increase of cancer metastasis in lymph nodes (P < 0.01). Liver cancer patients with upregulated expression of GTPBP4 showed a shorter overall survival rate (P=0.02). GTPBP4 is closely related to genes such as NIFK, WDR12, and RPF2, and these genes are involved in life processes such as GTP binding and rRNA processing. The upregulated expression of GTPBP4 promotes the proliferation of liver cancer cells and promotes the growth of tumors in mice, while the downregulated expression of GTPBP4 inhibits the proliferation of liver cancer cells and inhibits the growth of tumors in mice. The expression of GTPBP4 is upregulated in liver cancer patients and affects the overall survival rate of patients. The upregulated expression of GTPBP4 promotes the proliferation of liver cancer cells and the growth of tumors.