Molecular basis and clinical application of biological markers of bone turnover.
Molecular basis and clinical application of biological markers of bone turnover.
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DOI：
10.1210/edrv-17-4-333
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发表时间：
1996-08
影响因子：
20.3
通讯作者：
M. Calvo;D. Eyre;C. Gundberg
中科院分区：
文献类型：
--
作者：
M. Calvo;D. Eyre;C. Gundberg
一套理想的测试应该包括骨吸收和骨形成的指标。它们应该是骨骼特有的，反映骨骼的总体活动，并且应该与骨重塑活动的传统测量相关，如放射性钙动力学、组织形态测量或骨量变化。干扰其测量的因素，如昼夜节律、饮食、年龄、性别、骨量、肝功能和肾脏清除率，应明确界定（图9）。到目前为止，还没有建立骨标记物来满足所有这些标准，每个标记物可能有其特定的优点和局限性。在对从任何骨标记测量中获得的信息有完全的信心之前，仍然有一些问题必须得到回答。此外，应该强调的是，这些标记物都不能诊断任何特定的骨病，也不能用于个别患者的诊断。然而，研究和发展的最新进展提供了特异性、敏感性和可用性更高的检测方法。正因为如此，骨标记物可以用于各种重要目的：作为基础骨生物学研究的工具，在临床研究或药物试验中定义一般生理现象，以及跟踪个体患者。
An ideal battery of tests would include indices of bone resorption and formation. They should be unique to bone, reflect total skeletal activity, and should correlate with traditional measures of bone remodeling activity, such as radiocalcium kinetics, histomorphometry, or changes in bone mass. Factors that confound their measurement, such as circadian rhythms, diet, age, sex, bone mass, liver function, and kidney clearance rates, should be clearly defined (Fig. 9). To date, no bone marker has been established to meet all these criteria, and each marker may have its own specific advantages and limitations. There are still questions that must be answered before there can be complete confidence in the information gained from measurement of any of the bone markers. Furthermore, it should be emphasized that none of the markers are diagnostic for any particular bone disease and cannot be used for this purpose in individual patients. Nevertheless, recent advances in research and development have provided assays with increased specificity, sensitivity, and availability. Because of this, bone markers can be used for a variety of important purposes: as tools for basic bone biology research, for defining general physiological phenomenon in clinical studies or drug trials, and for following individual patients.