Negligible role of CSF cations other than Na+ in the central regulation of ADH release.
Negligible role of CSF cations other than Na+ in the central regulation of ADH release.
复制标题
除 Na 以外的 CSF 阳离子在 ADH 释放的中枢调节中的作用可以忽略不计。
DOI：
10.1111/j.1748-1716.1976.tb10280.x
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
L. Eriksson
中科院分区：
文献类型：
--
作者：
L. Eriksson
以前的实验在山羊（cf. Andersson 1971）提出，第三脑室附近的钠敏感受体系统参与抗利尿激素（ADH）分泌的调节。通过将纯糖溶液输注到侧脑室和第三脑室的脑脊液（CSF）中，进一步支持了这一概念（Eriksson 1974）。结果发现，这种输注，这明显降低CSF [Na+]，诱导水利尿在非水合山羊。然而，不能排除除Na+以外的其他离子的CSF浓度降低是否对观察到的ADH释放抑制具有重要意义。本研究的结果似乎排除了这种可能性。
Previous experiments in the goat (cf. Andersson 1971) have suggested that a sodium sensitive receptor system near the third cerebral ventricle participates in the regulation of antidiuretic hormone (ADH) secretion. Further support for this concept has been obtained by infusions of pure saccharide solutions into the cerebrospinal fluid (CSF) of the lateral and third cerebral ventricles (Eriksson 1974). It was found that such infusions, which obviously reduce CSF [Na+], induce water diuresis in non-hydrated goats. However, it could not be excluded whether reduced CSF concentration of ions other than Na+ might be of importance for the observed inhibition of ADH release. The results of the present study seem to exclude this possibility.