Electron microscopic observations on the rheumatoid synovial membrane
Electron microscopic observations on the rheumatoid synovial membrane
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类风湿滑膜的电镜观察
DOI：
10.1002/art.1780090405
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发表时间：
1966
影响因子：
--
通讯作者：
M. Ziff
中科院分区：
文献类型：
--
作者：
W. Norton;M. Ziff
材料与方法从19例确诊类风湿性关节炎患者和3例幼年类风湿性关节炎患者中分别获得21例（表1）和3例（表1）。致敏羊细胞凝集试验表明，所有成人类鼻炎患者均有类风湿因子。滴度范围为1/28至1/448。所有幼鱼血清均为阴性。除了一个标本外，所有标本都是在外科手术中经过各种程序获得的。该标本来自成人，通过针活检获得。6 19名成年和3名青少年中的3名在活检时接受类固醇治疗。所有患者在手术前两周内均未接受关节内类固醇注射。最大剂量为7.5毫克。每天强的松。3例患者，2例成人，1例青少年，0.5 ~ 1.0 id。在手术前1小时注射0.25%的胶体金悬浮液~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~ ~~。
MATERIALS AND METHODSTwenty-one sytiovial biopsy specimens (Table 1) were ohtained from 19 patients with definite rheuriiatoid arthritis according to ARA criteria and three from three patients with juvenile rheumatoid. All adult rhenniatoid patients had rheuriiatoicl factor by the sensitized sheep cell agglutiiiatiori test. with titers ranging from 1/28 to 1/448. All juveniles were seronegative. All hut one specinien wrre obtained at surgery in the course of a variety of procedures. This specimen, from an adult, was obtained by needle biopsy. 6 Three of 19 adults arid 3 of 3 juveniles were receiving steroid therapy at the time of biopsy. None of the patients had received intra-articular steroid injections within two weeks prior to surgery. The maxirnirm dose was 7.5 ing. prednisolone daily. In three patients, two adult and one juvenile, 0.5 to 1.0 id. of 0.25 per cent colloidal gold suspension was injected intr~~-~~ rti~ i, l~ rl~~ one hour prior to s~ irgery.