Immunogenetics of human echinococcosis.
Immunogenetics of human echinococcosis.
复制标题
DOI：
10.1016/j.pt.2012.08.001
复制
发表时间：
2012-10
影响因子：
9.6
通讯作者：
Yurong Yang;M. Ellis;D. McManus
中科院分区：
文献类型：
--
作者：
Yurong Yang;M. Ellis;D. McManus
虽然对人类棘球蚴感染和疾病的易感性和抵抗力知之甚少，但似乎反映了寄生虫与宿主免疫和遗传因素的复杂相互作用。治疗后的疾病阶段、进展和预后似乎受到细胞因子和抗体谱的强烈影响，最近的证据表明树突状细胞（DC）和调节性T细胞（TCFs）在免疫调节中起重要作用。微阵列支持这些发现，突出了慢性鼠疾病中涉及的已知和新途径。迄今为止，基因研究很少，而且成功有限。先进的基因组方法，如全基因组关联研究（GWAS），可以提供进一步的见解，以确定相关的途径，从而促进新的临床疗法的发展的新方法。
Susceptibility and resistance to humanEchinococcusinfection and disease, although poorly understood, appear to reflect a complex interaction of parasite and host immunological and genetic factors. Disease stage, progression, and prognosis following treatment appear to be strongly influenced by cytokine and antibody profiles, and more recent evidence has suggested an important role of dendritic cells (DCs) and T regulatory cells (Tregs) in immunomodulation. Microarrays have supported these findings, highlighting both known and novel pathways involved in chronic murine disease. Genetic studies to date have been few and with limited success. Advanced genomic approaches, such as genome-wide association studies (GWAS), may provide further insight to identify the relevant pathways involved, thereby facilitating a new approach for the development of new clinical therapies.