SEX-DIFFERENTIATION OF THE CIRCADIAN SYSTEM IN THE GOLDEN-HAMSTER
SEX-DIFFERENTIATION OF THE CIRCADIAN SYSTEM IN THE GOLDEN-HAMSTER
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DOI：
10.1152/ajpregu.1980.238.1.r97
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
MORIN, LP
中科院分区：
文献类型：
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作者：
ZUCKER, I;FITZGERALD, KM;MORIN, LP
研究了雌二醇苯甲酸酯（estradiol benzoate， EB）在持续昏暗光照下对去性腺的仓鼠自由运行的昼夜活动节律的影响。EB缩短了雌性的生理周期（.tau.），但没有缩短雄性的生理活动节律。昼夜节律系统对EB的反应受到性别分化的影响。雌性仓鼠在出生当天注射单次丙酸睾酮，成年后对EB的反应没有缩短其跑轮的昼夜周期。正常雄性仓鼠对EB没有反应，这与正常雌性仓鼠的反应不同。.tau。出生当天阉割的雄性在成年期接受EB治疗时活动节律缩短。雌二醇对。tau的不同影响。与生理节律基质的神经连接的两性解剖差异有关。
The effect of estradiol benzoate (EB) on free-running circadian activity rhythms was studied in gonadectomized hamsters maintained in constant dim illumination. EB shortened the period (.tau.) of the female, but not of the male circadian activity rhythm. Responsiveness of the circadian system to EB was subject to sexual differentiation. The circadian period of wheel running by female hamsters given a single injection of testosterone propionate on the day of birth did not shorten in response to EB in adulthood. This failure to respond to EB was seen in normal male hamsters, and was different from the response shown by normal females. The .tau. of the activity rhythm of males castrated on the day of birth is shortened during EB treatment in adulthood. The differential effects of estradiol on .tau. are related to anatomic differences between the sexes in neural connections of the substrate for circadian rhythms.