Behavioral paradigms to evaluate PPAR modulation in animal models of brain injury.

Behavioral paradigms to evaluate PPAR modulation in animal models of brain injury.
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评估脑损伤动物模型中 PPAR 调节的行为范式。

DOI:
10.1007/978-1-62703-155-4_24
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发表时间:
2013
期刊:
Methods in molecular biology (Clifton, N.J.)
影响因子:
--
通讯作者:
Robbins,MikeE
Robbins,MikeE
中科院分区:
--
文献类型:
--
作者:
Greene-Schloesser,Dana;Schnegg,CarolineI;Robbins,MikeE

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行为测试的使用已成为评估各种中枢神经系统疾病治疗效果的宝贵工具。本章将详细描述几种行为范例,以评估PPAR激动剂调节啮齿动物模型中认知障碍的功效。当这些程序作为一组程序一起使用时,可以对认知进行全面评估。这些测试在下面详细解释,并且包括:(1)新对象识别(NOR),(2)莫里斯水迷宫(MWM),(3)延迟匹配到位置(Delay Match to Place),以及(4)提示策略。
The use of behavioral testing has become an invaluable tool for assessing the efficacy of therapeutics for a variety of disorders of the central nervous system. This chapter will describe in detail several behavioral paradigms to evaluate the efficacy of PPAR agonists to modulate cognitive impairments in rodent models. When used together as a battery these procedures allow for a global assessment of cognition. These tests are explained in detail below, and include: (1) Novel Object Recognition (NOR), (2) Morris Water Maze (MWM), (3) Delay Match to Place (DMP), and (4) Cue Strategy.
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