Programmable Permeability of Metal-Phenolic Network Microcapsules
Programmable Permeability of Metal-Phenolic Network Microcapsules
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DOI：
10.1021/acs.chemmater.0c02279
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发表时间：
2020-08-25
影响因子：
8.6
通讯作者：
Caruso, Frank
中科院分区：
文献类型：
--
作者：
Chen, Jingqu;Pan, Shuaijun;Caruso, Frank
开发用于货物封装和释放的具有可编程渗透性的材料具有挑战性，但在包括药物输送和传感在内的许多领域都很重要。金属酚网络 (MPN) 是一类新兴的混合配位材料，具有 pH 响应性和模块化性，可设计成用于多种应用的功能薄膜。在此，我们通过调整胶囊中的分子间相互作用，设计了具有动态门控机制的基于 MPN 的微胶囊。改变结构单元和前体比例的选择提供了定制胶囊尺寸和渗透性的内在和模块化方法。或者，调节环境的 pH 值，从而调节 MPN 的质子化状态，从本质上使胶囊能够在高渗透性（> 90% 的胶囊在 pH 9 时可渗透）和近不可渗透（
Developing materials with programmable permeability for cargo encapsulation and release is challenging but important in a number of fields including drug delivery and sensing. Metal-phenolic networks (MPNs) are an emerging class of hybrid coordination materials with pH responsiveness and modularity that can be engineered into functional thin films for diverse applications. Herein, we engineer MPN-based microcapsules with a dynamic gating mechanism by adjusting the intermolecular interactions in the capsules. Altering the choice of building blocks and the precursor ratio provides an intrinsic and modular means of tailoring capsule size and permeability. Alternatively, regulating the pH of the environment, and thereby the protonation states of MPNs, extrinsically enables capsules to switch between highly permeable (>90% of capsules permeable at pH 9) and near-impermeable (