In vitro evaluation of antifungal properties of 8.O.4'-neolignans
In vitro evaluation of antifungal properties of 8.O.4'-neolignans
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DOI：
10.1021/np9605504
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发表时间：
1997-07-01
影响因子：
5.1
通讯作者：
Sierra, MG
中科院分区：
文献类型：
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作者：
Zacchino, S;Rodriguez, G;Sierra, MG
采用琼脂稀释法对18种外消旋8.O.4 '-新木脂素的抗真菌活性进行了评价，这些外消旋8.O.4'-新木脂素在A环和B环、酮、β-和三种醇形式中具有6种不同的取代模式。只有醇类对犬小孢子菌、石膏样小孢子菌、须毛癣菌、红色毛癣菌和絮状表皮癣菌表现出广谱活性。（+/-）-邻位-3，4-（亚甲二氧基）-7-羟基-1 '-烯丙基-3 '5'-二甲氧基-8.O.4 '-新木脂素（11）是该系列化合物中活性最高的化合物，E.其中，绒毡毛蕨最敏感。
Eighteen racemic 8.O.4'-neolignans with six different substitution patterns in rings A and B, in their ketone and in their erythro and three alcoholic forms, were evaluated for antifungal activity by the agar dilution method. Only the alcohols exhibited a broad spectrum of activities against Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, Tricophyton rubrum, and Epidermophyton floccosum. (+/-)-erythro-3,4-(methylenedioxy)-7-hydroxy-1'-allyl-3'5'-dimethoxy-8.O.4'-neolignan (11) was the most active compound in the series, and E. floccosum was the most susceptible species.