ASSESSMENT OF INFLAMMATION IN NONINFECTIOUS CHRONIC MAXILLARY SINUSITIS
ASSESSMENT OF INFLAMMATION IN NONINFECTIOUS CHRONIC MAXILLARY SINUSITIS
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DOI：
10.1016/0091-6749(94)90076-0
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发表时间：
1994-07-01
影响因子：
14.2
通讯作者：
BOUSQUET, J
中科院分区：
文献类型：
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作者：
DEMOLY, P;CRAMPETTE, L;BOUSQUET, J
背景和目的：通过鼻窦粘膜病理检查和鼻窦液中炎症介质滴定来表征慢性鼻窦炎的炎症特征，并确定慢性变应性鼻炎（CAR）和鼻窦炎患者与慢性非变应性鼻炎（CNAR）和鼻窦炎患者是否不同。方法：9名中心受试者（需要与鼻窦炎无关的耳鼻喉手术的患者），12名CAR和鼻窦炎患者，13名CNAR和鼻窦炎患者。进行了鼻窦炎检查。测定鼻窦灌洗液中的嗜酸性粒细胞阳离子蛋白、类胰蛋白酶、髓过氧化物酶、组胺和前列腺素D-2，并对细胞进行计数。使用针对嗜酸性粒细胞阳离子蛋白（嗜酸性粒细胞）、类胰蛋白酶（肥大细胞）、中性粒细胞弹性蛋白酶（中性粒细胞）、CD3（淋巴细胞）、CD68（巨噬细胞）和增殖细胞核抗原的单克隆抗体，通过免疫组织化学研究细胞浸润。结果：鼻窦炎中中性粒细胞没有增加。与对照受试者相比，患有鼻窦炎的CAR和CNAR患者的活检标本中的嗜酸性粒细胞和巨噬细胞以及鼻窦灌洗液中的嗜酸性粒细胞阳离子蛋白显着增加。与 CNAR 患者相比，CAR 患者的上皮内肥大细胞和淋巴细胞数量增加。 结论：这些发现表明，CNAR 合并鼻窦炎的患者可以与 CAR 合并鼻窦炎的患者区分开来，后者类似于伴有嗜酸性粒细胞增多综合征的非过敏性鼻炎。
Background and aim: Pathologic examination of the sinus mucosa and titration of inflammatory mediators in the sinus fluid were carried out to characterize inflammation in chronic sinusitis and determine whether patients with chronic allergic rhinitis (CAR) and sinusitis differ from patients with chronic nonallergic rhinitis (CNAR) and sinusitis.Methods: Nine central subjects (patients requiring ear; nose, and throat surgery not related to sinusitis), 12 patients with CAR and sinusitis, and 13 patients with CNAR and sinusitis were investigated. Eosinophil cationic protein, tryptase, myeloperoxidase, histamine, and prostaglandin D-2 were measured in the sinus lavage fluids, and cells were enumerated. The cellular infiltrate was studied by immunohistochemistry with monoclonal antibodies against eosinophil cationic protein (eosinophils), tryptase (mast cells), neutrophil elastase (neutrophils), CD3 (lymphocytes), CD68 (macrophages), and proliferating cell nuclear antigens.Results: Neutrophils were not increased in sinusitis. In comparison with control subjects, patients with CAR and CNAR with sinusitis showed significant increases in eosinophils and macrophages in biopsy specimens and in eosinophil cationic protein in sinus lavage fluids. In comparison with patients with CNAR, patients with CAR had an increased number of intraepithelial mast cells and lymphocytes.Conclusions: These findings suggest chat patients with CNAR and sinusitis can be distinguished from patients with CAR and sinusitis, which resembles nonallergic rhinitis with eosinophilia syndrome.