3D-printed adaptive acoustic lens as a disruptive technology for transcranial ultrasound therapy using single-element transducers
3D-printed adaptive acoustic lens as a disruptive technology for transcranial ultrasound therapy using single-element transducers
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DOI：
10.1088/1361-6560/aaa037
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发表时间：
2018-01-01
影响因子：
3.5
通讯作者：
Aubry, Jean-Francois
中科院分区：
文献类型：
--
作者：
Maimbourg, Guillaume;Houdouin, Alexandre;Aubry, Jean-Francois
为了更好地控制超声波束的形状，多元件阵列的发展为通过高度畸变的介质（如人类头骨）聚焦开辟了道路。因此，经颅聚焦超声脑部治疗的使用迅速增长。虽然这种技术很有效，但价格昂贵。我们提出了一种破坏性的，低成本的方法，该方法包括通过人类头骨聚焦1 MHz的超声波束，该方法具有单元件换能器，该换能器与在3D打印模具中铸造的定制的硅树脂声学透镜相耦合，并使用基于计算机断层扫描的数值声学模拟进行设计。我们证明N = 3人头骨，增加基于透镜的像差校正的单元件换能器增加了10倍的目标上的沉积能量。
The development of multi-element arrays for better control of the shape of ultrasonic beams has opened the way for focusing through highly aberrating media, such as the human skull. As a result, the use of brain therapy with transcranial-focused ultrasound has rapidly grown. Although effective, such technology is expensive. We propose a disruptive, low-cost approach that consists of focusing a 1 MHz ultrasound beam through a human skull with a single-element transducer coupled with a tailored silicone acoustic lens cast in a 3D-printed mold and designed using computed tomography-based numerical acoustic simulation. We demonstrate on N = 3 human skulls that adding lens-based aberration correction to a single-element transducer increases the deposited energy on the target 10 fold.