Resting Heart Rate Variability, Inflammation, and Insulin Resistance in Overweight and Obese Adolescents
Resting Heart Rate Variability, Inflammation, and Insulin Resistance in Overweight and Obese Adolescents
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DOI：
10.1089/met.2015.0140
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发表时间：
2016-08-01
影响因子：
2.1
通讯作者：
Jain, Sushil K.
中科院分区：
文献类型：
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作者：
Parish, Roy C.;Todman, Steven;Jain, Sushil K.
背景：在美国，肥胖症在年轻人中的流行率正在增加。最近，低度炎症被认为是伴随肥胖的，肥胖是2型糖尿病的已知危险因素。自主神经功能障碍是成人糖尿病的一个显著特征，但其在糖尿病前期或有糖尿病危险因素的青少年中的患病率尚不清楚。我们承诺研究肥胖，炎症，胰岛素抵抗，和自主神经功能障碍一起在人口中的青少年年龄在13-18 years.Methods：受试者提供了一个血液样本细胞因子分析和5分钟的静息心电图静息心率变异性分析。通过酶联免疫吸附试验分析TNF-α、IL-6、C-反应蛋白（CRP）、MCP-1和IL-10，并将傅立叶变换应用于R-R间期的心电图记录以进行频率空间分析。结果：肥胖组TNF-α、IL-6、CRP、MCP-1、HOMA和胰岛素水平均高于对照组，但血糖和IL-10水平均低于对照组。低频（0.04-0.15 Hz）和高频（0.15-0.4 Hz）波动的R-R间期较低的肥胖受试者，但标准化的低频功率是没有不同的，这表明成比例的减少变异范围和损害的交感神经和副交感神经系统。慢性低度炎症、胰岛素抵抗和自主神经功能障碍存在于肥胖青年的早期;早期发现炎症可能有助于这一高危人群有意义的生活方式改变。
Background: The prevalence of obesity is increasing in young people in the United States. Lately, low-grade inflammation is recognized as accompanying obesity, a known risk factor for type 2 diabetes. Autonomic dysfunction is a prominent feature of adult diabetes, but its prevalence in adolescents in prediabetic states or with diabetes risk factors is unknown. We undertook to study obesity, inflammation, insulin resistance, and autonomic dysfunction together in a population of adolescents aged 13-18 years.Methods: Subjects gave a blood sample for cytokine analysis and a 5-min resting EKG for analysis of resting heart rate variability. TNF-alpha, IL-6, c-reactive protein (CRP), MCP-1, and IL-10 were analyzed by enzyme-linked immunosorbent assay, and Fourier Transform was applied to electrocardiographic recordings of R-R intervals for analysis in frequency space. The HOMA calculation was used as an index of insulin sensitivity.Results: TNF-alpha, IL-6, CRP, MCP-1, HOMA, and insulin levels, but not serum glucose or IL-10, were higher in the obese subjects. Low-frequency (0.04-0.15 Hz) and high-frequency (0.15-0.4 Hz) fluctuations of R-R intervals were lower in the obese subjects, but the normalized low-frequency power was not different, suggesting proportional reduction in variability in both ranges and impairment of both sympathetic and parasympathetic systems.Conclusions: Chronic low-grade inflammation, insulin resistance, and autonomic dysfunction are present at an early age in obese youths; early detection of inflammation may facilitate meaningful lifestyle changes in this high-risk group.