Knock out models to dissect chemokine receptor function in vivo
Knock out models to dissect chemokine receptor function in vivo
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DOI：
10.1016/s0022-1759(02)00419-2
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发表时间：
2003-02-01
影响因子：
2.2
通讯作者：
Power, CA
中科院分区：
文献类型：
--
作者：
Power, CA
趋化因子是一类小蛋白家族，参与多种生物学过程，从造血、血管生成、淋巴细胞转运到白细胞对炎症介质、组织损伤和细菌或病毒感染的渗出和组织渗透。趋化因子通过与G蛋白偶联的七种跨膜受体结合发挥作用。体外研究表明，趋化因子系统是高度冗余的，因为大多数趋化因子与一个以上的受体结合，并且大多数受体与多个趋化因子结合。因此，靶向删除趋化因子受体已被证明是一种有用的工具来确定这些分子在体内的不同生物学作用。(C)2002 Elsevier Science B.V.保留所有权利。
Chemokines are a family of small proteins involved in numerous biological processes ranging from hematopoiesis, angiogenesis and lymphocyte trafficking to the extravasation and tissue infiltration of leukocytes in response to inflammatory agents, tissue damage and bacterial or viral infection. Chemokines exert their effects by binding to specific G-protein-coupled seven-transmembrane receptors. In vitro studies suggest that the chemokine system is highly redundant in that most chemokines bind to more than one receptor and most receptors bind multiple chemokines. Therefore, targeted deletion of chemokine receptors has proved to be a useful tool for determining the distinct biological role of these molecules in vivo. (C) 2002 Elsevier Science B.V. All rights reserved.