CORONARY BLOOD-FLOW MEASUREMENT USING AN ANGIOGRAPHIC 1ST PASS DISTRIBUTION TECHNIQUE - A FEASIBILITY STUDY
CORONARY BLOOD-FLOW MEASUREMENT USING AN ANGIOGRAPHIC 1ST PASS DISTRIBUTION TECHNIQUE - A FEASIBILITY STUDY
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DOI：
10.1118/1.596716
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发表时间：
1991-09-01
期刊：
影响因子：
3.8
通讯作者：
MISTRETTA, CA
中科院分区：
文献类型：
--
作者：
HANGIANDREOU, NJ;FOLTS, JD;MISTRETTA, CA
由于与冠状动脉血管造影片的视觉解释相关的问题，正在研究更多的生理手段来评估冠状动脉狭窄。 已经提出的一个生理参数是冠状动脉血流储备（CFR）。 提出了一种基于首过分布分析（FPA）的数字减影血管造影技术，用于测量CFR和绝对冠状动脉流量。 首先概述了FPA方法的理论，并描述了FPA算法的初步版本的实现。 实验验证该算法的实用性，用于测量绝对流量通过流量幻影，并通过犬回旋动脉的报告。 经确定，初步FPA算法能够测量犬冠状动脉流量比（R），其准确度和精密度特性满足或超过参数成像技术报告的准确度和精密度特性（R（FPA）= 0.933.R（真），SEE = 0.16，r = 0.984）。 在所有体模实验中（Q（FPA）= 1.054.Q（真），r = 0.993）和研究的三只犬中的一只中（Q（FPA）= Q（真），r = 0.935）获得了准确的绝对流量（Q）测量值。 在另外两个狗实验中遇到的困难归因于系统时间滞后的影响，并且可能通过使用改进的相机来校正。 建立了测量相对流量的一般FPA方法的可行性，并证明了常规绝对流量测量的潜力。
Due to the well-documented problems associated with visual interpretation of coronary angiograms, more physiologic means of assessing coronary artery stenosis are being investigated. One physiologic parameter that has been suggested is coronary flow reserve (CFR). A digital subtraction angiographic technique based on first pass distribution analysis (FPA) is proposed as a means of measuring CFR and absolute coronary flow. The theory of the FPA method is first outlined, and the implementation of a preliminary version of the FPA algorithm is described. Experiments verifying the utility of this algorithm for measuring absolute flow through a flow phantom, and through the canine circumflex artery are reported. It was determined that the preliminary FPA algorithm is capable of measuring canine coronary flow ratios (R) with accuracy and precision characteristics meeting or exceeding those reported for the parametric imaging technique (R(FPA) = 0.933.R(true), SEE = 0.16, r = 0.984). Accurate absolute flow (Q) measurements were obtained in all of the phantom experiments (Q(FPA) = 1.054.Q(true), r = 0.993), and in one of the three dogs that were studied (Q(FPA) = Q(true), r = 0.935). The difficulty encountered in the other two dog experiments is attributed to the effects of system temporal lag, and would likely be corrected through the use of improved cameras. The feasibility of the general FPA method for measuring relative flow is established, and the potential for routine, absolute flow measurement is demonstrated.