Aberrantly regulated proteins in frontotemporal dementia.
Aberrantly regulated proteins in frontotemporal dementia.
复制标题
额颞叶痴呆中异常调节的蛋白质。
DOI：
10.1016/j.bbrc.2006.07.113
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发表时间：
2006
影响因子：
3.1
通讯作者：
Murrell,Jill
中科院分区：
文献类型：
--
作者：
Schweitzer,Kelly;Decker,Emily;Zhu,Liping;Miller,RichardE;Mirra,SuzanneS;Spina,Salvatore;Ghetti,Bernardino;Wang,Mu;Murrell,Jill
额叶型非阿尔茨海默病，或额颞叶痴呆（FTD），是第二种最常见的痴呆形式。然而，对这种疾病的详细描述特别有限。为了鉴定可能涉及疾病病理或进展的机制，对从患有与染色体17（FTDP-17）相关的额颞叶痴呆和帕金森综合征的人额叶皮质分离的蛋白质进行蛋白质组学分析。我们使用2D凝胶电泳和MALDI-TOF鉴定了FTDP-17中共24个差异表达的蛋白。我们确定了一个泛素C-末端水解酶，UCHL 1，以及参与氧化应激的几个蛋白质差异表达。所呈现的数据涉及UCHL 1和泛素介导的降解以及疾病病理或进展中的氧化应激反应。
Non-Alzheimer’s disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolated from human frontal cortex with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several proteins involved in oxidative stress to be differentially expressed. Data presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative stress response in disease pathology or progression.