DYNAMIC CHANGES IN SPLANCHNIC BLOOD FLOW AND BLOOD VOLUME IN DOGS DURING ACTIVATION OF SYMPATHETIC NERVES
DYNAMIC CHANGES IN SPLANCHNIC BLOOD FLOW AND BLOOD VOLUME IN DOGS DURING ACTIVATION OF SYMPATHETIC NERVES
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DOI：
10.1161/01.res.29.3.227
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发表时间：
1971-01-01
影响因子：
20.1
通讯作者：
DONALD, DE
中科院分区：
文献类型：
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作者：
BROOKSBY, GA;DONALD, DE
在25只麻醉犬上，用电磁方波流量传感器同时测量了内脏区的动脉流入和静脉流出。内脏血容量（SBV）的变化计算为流入和流出之间的瞬时差异。增加通过改变颈动脉窦压力相对于对照值诱导的SBV的相应增加和减少（平均136 mm Hg）至200或40 mm Hg时，平均总血量为93 ml（SD，±21.7），可从内脏循环反射性动员，电刺激（15 v，2 cps，3 msec持续时间）左胸内脏神经2至10 min，使SBV减少159 ml血液（SD，±84）。这些平均值分别占总SBV计算值的32%和48%。在这两种情况下，血液的易位是迅速的，内脏血流量和SBV的总变化的50%发生在30秒内。在2分钟出血（7.2 ml/kg）期间，从内脏区域动员的平均血量为56 ml（SD，±16）。这占总流血的量的54%。在这种情况下，血液以相当恒定的速率流出内脏循环。
Arterial inflow to and venous outflow from the vascularly isolated splanchnic region were measured simultaneously by using cannulating electromagnetic square-wave flow transducers in 25 anesthetized dogs with intact abdomens. Change in splanchnic blood volume (SBV) was calculated as the instantaneous difference between inflow and outflow. Addition of the respective increases and decreases in SBV induced by changing carotid sinus pressure from the control value (mean, 136 mm Hg) to 200 or to 40 mm Hg gave an average total volume of 93 ml of blood (SD, ±21.7) that could be mobilized reflexly from the splanchnic circulation, Electrical stimulation (15 v, 2 cps, 3 msec duration) of the left thoracic splanchnic nerve for 2 to 10 minutes decreased SBV by 159 ml of blood (SD, ±84). These mean values represent 32 and 48%, respectively, of the calculated total SBV. In both situations the translocation of blood was rapid, 50% of the total change in splanchnic blood flow and SBV occurring within 30 seconds. During a 2-minute hemorrhage (7.2 ml/kg), a mean volume of 56 ml of blood (SD, ±16) was mobilized from the splanchnic region. This represented 54% of the total volume bled. Under these circumstances, blood moved out of the splanchnic circulation at a fairly constant rate.