Mucosal stimulation evokes vasodilation in submucosal arterioles by neuronal and nonneuronal mechanisms.
Mucosal stimulation evokes vasodilation in submucosal arterioles by neuronal and nonneuronal mechanisms.
复制标题
粘膜刺激通过神经元和非神经元机制引起粘膜下小动脉的血管舒张。
DOI：
10.1152/ajpgi.1993.264.2.g202
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Surprenant,A
中科院分区：
文献类型：
--
作者：
Vanner,S;Jiang,MM;Surprenant,A
本文用离体培养的豚鼠回肠粘膜下微动脉血管丛和粘膜的视频显微镜观察了机械刺激对回肠粘膜下微动脉的影响。粘液刺激并没有改变松弛血管的直径，但扩张的小动脉与苯肾上腺素或前列腺素类似物U-46619预收缩。河豚毒素（TTX）或毒蕈碱受体拮抗剂抑制粘膜刺激诱发的血管舒张反应，在60%的正常和extrapereddenervated动物检查的准备工作。5-羟色胺3（5-HT 3）受体拮抗剂ICS 205930可部分抑制对粘膜刺激的TTX敏感性血管舒张。当应用组胺受体拮抗剂西咪替丁和吡拉明以及前列腺素合成抑制剂吲哚美辛时，在很大程度上防止了TTX不敏感的血管舒张。这项研究表明，在一个孤立的粘膜下神经丛准备，涉及神经元和非神经元途径的粘膜刺激反射性血管扩张。神经元通路会聚于粘膜下神经节中的胆碱能血管扩张神经元。非神经元途径涉及5-HT、组胺和肾上腺素从粘膜成分的释放; 5-HT兴奋胆碱能血管扩张神经元，而组胺和肾上腺素直接扩张粘膜下小动脉。
The effects of mechanical stimulation of intestinal mucosa on submucosal arterioles of guinea pig ileum were examined using video microscopy of in vitro preparations consisting of submucosal plexus with adjacently attached mucosa. Mucosal stimulation did not alter the diameter of relaxed vessels but dilated arterioles preconstricted with phenylephrine or the prostaglandin analogue U-46619. Tetrodotoxin (TTX) or muscarinic receptor antagonists inhibited the vasodilation evoked by mucosal stimulation in 60% of preparations examined from normal and extrinsically denervated animals. The TTX-sensitive vasodilation to mucosa stimulation was partially inhibited by the 5-hydroxytryptamine3 (5-HT3) receptor antagonist ICS 205930. The TTX-insensitive vasodilation was largely prevented when the histamine receptor antagonists cimetidine and pyrilamine and the prostaglandin synthesis inhibitor indomethacin were applied. This study has demonstrated a reflex vasodilation to mucosal stimulation in an isolated submucosal plexus preparation that involves both neuronal and nonneuronal pathways. The neuronal pathway converges on cholinergic vasodilator neurons in the submucosal ganglia. The nonneuronal pathway involves the release of 5-HT, histamine, and prostaglandins from mucosal elements; 5-HT excites cholinergic vasodilator neurons, whereas histamine and prostaglandins dilate submucosal arterioles directly.