Forebrain peptides modulate sexually polymorphic vocal circuitry
Forebrain peptides modulate sexually polymorphic vocal circuitry
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DOI：
10.1038/35001581
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发表时间：
2000-02-17
期刊：
影响因子：
64.8
通讯作者：
Bass, AH
中科院分区：
文献类型：
--
作者：
Goodson, JL;Bass, AH
肽精氨酸-加压素（哺乳动物）及其进化前体精氨酸-催产素（非哺乳动物）调节生殖生理学和许多相关的社会行为，催产素（哺乳动物）及其同系物中催产素和异催产素（鱼类）也是如此（1）。这些肽在大脑中的分布和/或行为功能通常在性别之间（2-4）以及具有不同社会结构的物种之间（3，5，6）不同。在这里，我们提出的神经生理学证据表明，男性与女性的声音特征的典型共享模式的神经肽功能的女性，而不是同种男性。该plainfin见习鱼（Porichthys notatus）有两个男性变种不同的生殖策略和发声（一个关键的物种典型的行为，其不同的物理属性和上下文的使用，取决于变形的社会策略）（7，8）。前脑诱发的，有节奏的声音运动活动，精确地模仿自然的发声调制的精氨酸-催产素，异催产素和它们的拮抗剂提供给视前区-前下丘脑，在所有脊椎动物的行为整合的主要网站。肽有不同的影响，男性听觉法院女性（催产素敏感）比女性和偷偷产卵的男性（异催产素敏感），表明建立生殖相关的行为的神经调节机制，可以从性腺性别分离。
The peptide arginine-vasopressin (mammals) and its evolutionary precursor arginine-vasotocin (non-mammals) modulate reproductive physiology and numerous related social behaviours, as do oxytocin (mammals) and its homologues mesotocin and isotocin (fish)(1). The distributions in the brain and/or the behavioural functions of these peptides often differ between the sexes(2-4), and between species with divergent social structures(3,5,6). Here we present neurophysiological evidence that males with vocal characteristics typical of females share a pattern of neuropeptide function with females rather than conspecific males. The plainfin midshipman fish (Porichthys notatus) has two male morphs with different reproductive tactics and vocalizations (a key species-typical behaviour which varies in its physical attributes and contextual usage, depending on the morph's social strategy)(7,8). Forebrain-evoked, rhythmic vocal-motor activity that precisely mimics natural vocalizations was modulated by arginine-vasotocin, isotocin and their antagonists delivered to the preoptic area-anterior hypothalamus, a primary site for behavioural integration in all vertebrates. Peptides had different effects in males that acoustically court females (arginine-vasotocin-sensitive) than in females and sneak-spawning males (isotocin-sensitive), showing that the neuromodulatory mechanisms that establish reproduction-related behaviour can be dissociated from gonadal sex.