Trends in Outcomes of Patients With Ischemic Stroke Treated Between 2002 and 2016 Insights From a Chinese Cohort
Trends in Outcomes of Patients With Ischemic Stroke Treated Between 2002 and 2016 Insights From a Chinese Cohort
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DOI：
10.1161/circoutcomes.119.005610
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发表时间：
2019-12-01
影响因子：
6.9
通讯作者：
Liu, Ming
中科院分区：
文献类型：
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作者：
Liu, Junfeng;Zheng, Lukai;Liu, Ming
背景：目前对中国缺血性卒中患者预后的长期趋势知之甚少。我们的目的是评估中国过去15年来这些结果的纵向趋势，并探索这些趋势背后的可能因素。方法和结果：自2002年以来，在华西医院神经内科住院的缺血性脑卒中患者前瞻性连续入组中心登记研究，本研究分析了2002年至2016年期间卒中7天内住院患者的数据。将患者分为3个5年间隔进行时间分析。在整个样本和按年龄（≥ 65岁）分层的亚组中，比较卒中后3个月和12个月的死亡、残疾和死亡/残疾。为了探索与结局趋势相关的可能因素，将因素与结局时间之间的相互作用单独输入多变量logistic回归模型。在最终分析的6462例缺血性卒中患者中，3837例（59.4%）为男性，平均年龄为64.2岁（SD，13.7）。在15年的时间里，卒中发病的平均年龄和入院时的国立卫生研究院卒中量表评分显著降低（P
Background: Little is known about long-term trends in outcomes of patients with ischemic stroke in China. We aimed to assess longitudinal trends in these outcomes over the past 15 years in China and explore possible factors behind the trends. Methods and Results: Patients with ischemic stroke admitted to the Department of Neurology at West China Hospital were prospectively and consecutively enrolled in a central registry since 2002, and the present study analyzed data from those admitted to hospital within 7 days of stroke during the period 2002 to 2016. Patients were binned into three 5-year intervals for temporal analysis. Death, disability, and death/disability at 3 and 12 months after stroke were compared among the time intervals across the entire sample and in subsets stratified by age (= 65 years). To explore the possible factors related to the trends in outcomes, interaction between the factors and time on outcomes was entered separately into the multivariable logistic regression model. Of 6462 patients with ischemic stroke in the final analysis, 3837 (59.4%) were men, and mean age was 64.2 years (SD, 13.7). Mean age at stroke onset and National Institutes of Health Stroke Scale score at admission decreased significantly during the 15-year period (P