Visual-cognitive processing deficits in pediatric multiple sclerosis
Visual-cognitive processing deficits in pediatric multiple sclerosis
复制标题
DOI：
10.1177/1352458510391689
复制
发表时间：
2011-04-01
影响因子：
5.8
通讯作者：
Benedict, R. H. B.
中科院分区：
文献类型：
--
作者：
Smerbeck, A. M.;Parrish, J.;Benedict, R. H. B.
背景：多发性硬化症（MS）儿童可遭受严重的认知缺陷。本研究探讨了从成人文献中借用的两种视觉加工测试的敏感性和有效性，简明视觉空间记忆测试修订版（BVMTR）和符号数字模态测试（SDMT）。目的：通过比较儿童MS与健康对照组在BVMTR和SDMT上的表现，来检验儿童MS视觉加工不成比例地受到影响的假设。方法：我们研究了88名参与者（43名MS，45名对照）使用神经心理评估电池，包括智力，语言，视觉记忆和处理速度的措施。比较患者和人口统计学匹配的对照组，以确定哪些测试在儿科MS中最敏感。MS组和对照组在BVMTR总学习（t（84）= 4.04，p < 0.001，d = 0.87），BVMTR延迟回忆（t（84）= 4.45，p < 0.001，d = 0.96），SDMT（t（38）= 2.19，p = 0.035，d = 0.69）。两组在对抗命名和一般智力方面没有显著差异。探索BVMTR，SDMT和疾病特征之间的相关性的有效性系数与成人literature.Conclusions一致：本研究发现，BVMTR和SDMT可能是有用的，在评估儿童和青少年MS。
Background: Children with multiple sclerosis (MS) can suffer significant cognitive deficits. This study investigates the sensitivity and validity in pediatric MS of two visual processing tests borrowed from the adult literature, the Brief Visuospatial Memory Test-Revised (BVMTR) and the Symbol Digit Modalities Test (SDMT).Objective: To test the hypothesis that visual processing is disproportionately impacted in pediatric MS by comparing performance with that of healthy controls on the BVMTR and SDMT.Methods: We studied 88 participants (43 MS, 45 controls) using a neuropsychological assessment battery including measures of intelligence, language, visual memory, and processing speed. Patients and demographically matched controls were compared to determine which tests are most sensitive in pediatric MS.Results: Statistically significant differences were found between the MS and control groups on BVMTR Total Learning (t (84) = 4.04, p < 0.001, d = 0.87), BVMTR Delayed Recall (t (84) = 4.45, p < 0.001, d = 0.96), and SDMT (t (38) = 2.19, p = 0.035, d = 0.69). No significant differences were found between groups on confrontation naming or general intellectual ability. Validity coefficients exploring correlation between BVMTR, SDMT, and disease characteristics were consistent with the adult literature.Conclusions: This study found that BVMTR and SDMT may be useful in assessing children and adolescents with MS.