A low-intensity 10-min resistance exercise program that ameliorated hepatic fibrosis indices and altered G-CSF/IP-10/PDGF-BB in a patient with nonalcoholic fatty liver disease: A case report.
A low-intensity 10-min resistance exercise program that ameliorated hepatic fibrosis indices and altered G-CSF/IP-10/PDGF-BB in a patient with nonalcoholic fatty liver disease: A case report.
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DOI：
10.1002/jgh3.12876
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发表时间：
2023-03
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我们为非酒精性脂肪性肝病（NAFLD）开发了一种低强度10分钟抗阻运动计划。我们报告了一例NAFLD伴肝纤维化指数升高的病例，通过60周的每日运动计划得到改善。1例71岁女性NAFLD患者，其肝纤维化分期对应于F2，被转诊至我院。她每天进行一次锻炼，其他生活习惯和药物没有改变。稳态模型评估-胰岛素抵抗值和NAFLD-肝脏脂肪评分、Hepamet纤维化评分和增强的肝纤维化评分降低。FIB-4指数和Mac-2结合蛋白糖基化异构体的血清水平降低至参考值。我们研究了趋化因子/细胞因子的变化。血清粒细胞集落刺激因子水平升高，血清干扰素-γ-诱导蛋白-10和血小板衍生生长因子-BB水平降低。我们的计划可能有利于改善NAFLD患者的肝纤维化。运动是非酒精性脂肪肝（NAFLD）的一线疗法。我们开发了一个低强度的10分钟抗阻运动计划，其中包括六种运动（三种代谢当量）。我们的运动计划改善了NAFLD患者的肝纤维化。
We developed a low‐intensity 10‐min resistance exercise program for nonalcoholic fatty liver disease (NAFLD). We report a case of NAFLD with elevated hepatic fibrosis indices, which were improved by a 60‐week daily exercise program. A 71‐year‐old female patient with NAFLD whose hepatic fibrosis stage corresponded to F2 was referred to our hospital. She performed the exercise once a day with no changes in other lifestyle habits and medications. The homeostasis model assessment‐insulin resistance value and NAFLD‐liver fat score, the Hepamet fibrosis score, and the enhanced liver fibrosis score decreased. The FIB‐4 index and serum levels of Mac‐2 binding protein glycosylation isomer decreased to the reference values. We investigated the changes in chemokines/cytokines. The serum granulocyte‐colony stimulating factor level was increased, and serum interferon‐gamma‐induced protein‐10 and platelet‐derived growth factor‐BB levels were decreased. Our program may be beneficial for improving hepatic fibrosis in patients with NAFLD. Exercise is a first‐line therapy for nonalcoholic fatty liver disease (NAFLD). We developed a low‐intensity 10‐min resistance exercise program, which consists of six types of exercise (three metabolic equivalents). Our exercise program improved hepatic fibrosis in patients with NAFLD.