STUDIES ON THE MECHANISM OF ANTI-HYPERCHOLESTEROLEMIC ACTION OF SOY PROTEIN AND SOY PROTEIN-TYPE AMINO-ACID MIXTURES IN RELATION TO THE CASEIN COUNTERPARTS IN RATS
STUDIES ON THE MECHANISM OF ANTI-HYPERCHOLESTEROLEMIC ACTION OF SOY PROTEIN AND SOY PROTEIN-TYPE AMINO-ACID MIXTURES IN RELATION TO THE CASEIN COUNTERPARTS IN RATS
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DOI：
10.1093/jn/112.8.1614
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发表时间：
1982-01-01
影响因子：
4.2
通讯作者：
SUGANO, M
中科院分区：
文献类型：
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作者：
NAGATA, Y;ISHIWAKI, N;SUGANO, M
鉴于对大鼠具有降胆固醇作用的证据，与酪蛋白相比，大豆蛋白对胆固醇动态显示出以下影响：降低胆固醇吸收和增加粪便类固醇排泄；血清胆固醇更替更快；通过显着增加该隔室中的去除率，在不影响生产率的情况下，快速交换的胆固醇池（池A）的尺寸显着减小；以及体外和体内更大的肝脏甾体生成。相当于大豆蛋白的氨基酸混合物与酪蛋白型混合物相比显示出以下结果：对胆固醇吸收和粪便类固醇排泄没有影响；对血清胆固醇的周转没有影响；由于产量减少，A池规模缩小；以及在体外减少肝脏类固醇生成，但在体内则不然。这些结果表明，与酪蛋白相比，大豆蛋白具有抗高胆固醇作用，主要原因是肠道对胆固醇的吸收减少和粪便类固醇排泄增加。粪便中类固醇的损失远远超过肝脏类固醇生成的激活。就大豆蛋白型氨基酸混合物而言，肝脏胆固醇合成的抑制似乎是降低血清胆固醇水平的原因。
Given evidence of a hypocholesterolemic effect in rats, soy protein compared with casein showed the following effects on cholesterol dynamics: lower cholesterol absorption and greater fecal steroid excretion; more rapid turnover of serum cholesterol; a marked size reduction of the rapidly exchangeable cholesterol pool (pool A) through a significant increase in the removal rate in that compartment without influencing the production rate; and greater hepatic sterogenesis both in vitro and in vivo. The amino acid mixture equivalent to soy protein compared with casein-type mixture showed the following: no effects on cholesterol absorption and fecal steroid excretion; no effects on the turnover of serum cholesterol; the reduction of pool A size as a result of decreased production; and the reduction of hepatic steroidogenesis in vitro, but not in vivo. These results indicate that decreased intestinal absorption of cholesterol and increased fecal steroid excretion are primarily responsible for the antihypercholesterolemic effect of soy protein compared with casein. The fecal loss of steroids far outweighs the activation of hepatic steroidogenesis. In the case of the soy protein-type amino acid mixture, the depression of hepatic cholesterol synthesis seems accountable for reducing serum cholesterol levels.