Distinct developmental expression of Drosophila retinoblastoma factors
Distinct developmental expression of Drosophila retinoblastoma factors
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DOI：
10.1016/j.modgep.2004.09.005
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发表时间：
2005-02-01
影响因子：
1.2
通讯作者：
Arnosti, DN
中科院分区：
文献类型：
--
作者：
Keller, SA;Ullah, Z;Arnosti, DN
视网膜母细胞瘤（RB）肿瘤抑制蛋白是细胞周期的重要调节因子，与多种人类肿瘤有关。人类和模型系统中RB突变的遗传分析表明，单个RB蛋白在发育中也具有不同的功能。然而，个体RB蛋白在发育环境中的特定靶基因或作用机制尚不清楚。为了更好地了解果蝇的两个RB家族成员的发育活动，我们的特点是内源性表达模式的Rbf1和Rbf2蛋白和转录胚胎和成虫盘。这些基因产物在发育的几个阶段共表达，然而，空间和时间差异是明显的，包括在胚胎中枢神经系统中的部分互补的表达模式。(C)2004 Elsevier B.V.保留所有权利。
Retinoblastoma (RB) tumor suppressor proteins are important regulators of the cell cycle and are implicated in a wide variety of human tumors. Genetic analysis of RB mutations in humans and in model systems indicates that individual RB proteins also have distinct functions in development. Specific target genes or mechanisms of action of individual RB proteins in developmental contexts are not well understood, however. To better understand the developmental activities of the two RB family members in Drosophila, we have characterized endogenous expression patterns of Rbf1 and Rbf2 proteins and transcripts in embryos and imaginal discs. These gene products are coexpressed at several stages of development, however, spatial and temporal differences are evident, including partly complementary patterns of expression in the embryonic central nervous system. (C) 2004 Elsevier B.V. All rights reserved.