Functional connectivity of epileptogenic focus: detection and relationship with default mode network
Functional connectivity of epileptogenic focus: detection and relationship with default mode network
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DOI：
10.1109/iccme.2012.6275600
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发表时间：
2012-07
期刊：
影响因子：
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通讯作者：
Yoshiki Kaneoke;S. Maesawa;Y. Kajita;Toshihiko Wakabayashi;T. Nihashi;Shinji Naganawa
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文献类型：
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作者：
Yoshiki Kaneoke;S. Maesawa;Y. Kajita;Toshihiko Wakabayashi;T. Nihashi;Shinji Naganawa
功能磁共振成像（MRI）测量的慢振荡脑功能连通性（FC）分析已被证明有助于阐明人类大脑的神经网络活动。我们检查了医学上难治性病变相关性癫痫患者的致痫灶是否可以通过FC分析检测到。通过计算每个皮质体素与所有其他皮质体素的平均FC（两个体素之间的相关系数）来创建皮质中心区域图。在所有受试者的病灶周围都发现了相对高的皮质中枢区域，这与假定的致痫灶相对应。这些中枢与皮层下区域如基底神经节和丘脑有FC。6例继发性全身性癫痫患者，病变周围的中枢与后扣带皮层（vPCC）腹侧部有高FC。结果表明，皮质中枢图在检测致痫灶和从该灶传播癫痫信号的网络中是有用的。此外，假定焦点与vPCC之间的FC表明，即使在间隔状态下，来自焦点的异常信号也会干扰默认模式网络的正常功能。
Functional connectivity (FC) analysis with slow brain oscillation as measured by functional MRI has been shown to be useful in elucidating human brain's neural network activity. We examined if epileptogenic focus for the subjects with medically intractable lesion-related epilepsy could be detected by FC analysis. Cortical hub region map was created by calculating each cortical voxel's mean FC (correlation coefficient between the two voxels) to all other cortical voxels. Relatively high cortical hub regions were found around the lesions for all the subjects, which corresponded to the presumptive epileptogenic foci. These hubs had FC with the subcortical regions such as the basal ganglia and the thalamus. For 6 subjects with secondary generalized seizure, the hubs around the lesions had high FC with the ventral part of the posterior cingulate cortex (vPCC). The results suggest the usefulness of cortical hub map for the detection of epileptogenic focus and the networks involved in the propagation of seizure signals from the focus. Further, the FC between the presumptive focus and vPCC suggests that abnormal signal from the focus interferes the normal function of the default mode network even in inter-ictal state.