Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding
Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding
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DOI：
10.1111/1471-0528.16276
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发表时间：
2020-05-26
影响因子：
5.8
通讯作者：
Huang, H.
中科院分区：
文献类型：
--
作者：
Wu, Y.;Liu, C.;Huang, H.
目的评估2019年女性冠状病毒病患者的阴道分泌物和母乳（COVID-19）含有严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）。设计单中心队列研究。单位：武汉大学人民医院，湖北省武汉市，我们研究了2020年1月31日至3月9日期间确诊的13名SARS-CoV-2感染孕妇。方法收集临床资料，阴道分泌物，结果在13名COVID-19感染妇女中，5名处于妊娠早期，3名处于妊娠中期，5名处于妊娠晚期。在五名妊娠晚期分娩的妇女中，所有人都产下了活的新生儿。在这5次分娩中，主要的不良围产期结局包括早产（n = 2）和新生儿肺炎（n = 2）。9份粪便样本中有1份呈阳性;所有13份阴道分泌物样本，以及从新生儿身上采集的5份咽拭子和4份肛门拭子，对新型冠状病毒均呈阴性。结论在该病例系列的13名COVID-19孕妇中，我们观察到阴道分泌物标本的病毒检测结果为阴性，表明阴道分娩可能是一种安全的分娩选择。然而，我们迫切需要更多的研究来检查母乳和病毒污染的潜在风险。Tweetable abstract新的证据表明，感染SARS-CoV-2的孕妇阴道分娩和母乳喂养的安全性，母乳样本中的病毒结果呈阳性。
Objective To assess whether vaginal secretions and breast milk of women with coronavirus disease 2019 (COVID-19) contain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Design Single centre cohort study.Setting Renmin Hospital of Wuhan University, Wuhan, Hubei province, China.Population We studied 13 SARS-CoV-2-infected pregnant women diagnosed between 31 January and 9 March 2020.Methods We collected clinical data, vaginal secretions, stool specimens and breast milk from SARS-CoV-2-infected women during different stages of pregnancy and collected neonatal throat and anal swabs.Main outcomes and measures We assessed viral presence in different biosamples.Results Of the 13 women with COVID-19, five were in their first trimester, three in their second trimester and five in their third trimester. Of the five women in their third trimester who gave birth, all delivered live newborns. Among these five deliveries, the primary adverse perinatal outcomes included premature delivery (n = 2) and neonatal pneumonia (n = 2). One of nine stool samples was positive; all 13 vaginal secretion samples, and five throat swabs and four anal swabs collected from neonates, were negative for the novel coronavirus. However, one of three samples of breast milk was positive by viral nucleic acid testing.Conclusions In this case series of 13 pregnant women with COVID-19, we observed negative viral test results in vaginal secretion specimens, suggesting that a vaginal delivery may be a safe delivery option. However, additional research is urgently needed to examine breast milk and the potential risk for viral contamination.Tweetable abstract New evidence for the safety of vaginal delivery and breastfeeding in pregnant women infected with SARS-CoV-2, positive viral result in a breast-milk sample.