Rare sesquiterpenes from the algicolous fungus Drechslera dematioidea
Rare sesquiterpenes from the algicolous fungus Drechslera dematioidea
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DOI：
10.1021/np010092l
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发表时间：
2002-03-01
影响因子：
5.1
通讯作者：
Wright, AD
中科院分区：
文献类型：
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作者：
Osterhage, C;König, GM;Wright, AD
从海洋红藻 Liagora viscida 的内部组织中分离出真菌 Drechslera dematioidea。大规模培养后，对真菌的次生代谢产物含量进行了研究，并分离出 10 种新的倍半萜类化合物 [isosativenetriol (1)、drechslerines A (2) 和 B (3)、9-羟基蠕虫孢醇 (5)、drechslerines C-G (6-10) 和 sativene 环氧化物 (12)]。化合物8和10表现出针对恶性疟原虫的抗疟原虫活性。菌株K1和NF54。还分离出已知的化合物长蠕孢醇(4)、顺式-sativenediol (11)、异cochlioquinone A (14)、异cochlioquinone C (15) 和cochlioquinone B (16)。所有结构均使用光谱方法（主要是一维和二维核磁共振和质谱）阐明。
From the inner tissue of the marine red alga Liagora viscida the fungus Drechslera dematioidea was isolated. After mass cultivation, the fungus was investigated for its secondary metabolite content, and 10 new sesquiterpenoids [isosativenetriol (1), drechslerines A (2) and B (3), 9-hydroxyhelminthosporol (5), drechslerines C-G (6-10), and sativene epoxide (12)] were isolated. Compounds 8 and 10 exhibited antiplasmodial activity against Plasmodium falciparum. strains K1 and NF54. The known compounds helminthosporol (4), cis-sativenediol (11), isocochlioquinone A (14), isocochlioquinone C (15), and cochlioquinone B (16) were also isolated. All structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR and MS.