EFFECT OF PANTING FREQUENCY ON THE PLETHYSMOGRAPHIC DETERMINATION OF THORACIC GAS VOLUME IN CHRONIC OBSTRUCTIVE PULMONARY-DISEASE
EFFECT OF PANTING FREQUENCY ON THE PLETHYSMOGRAPHIC DETERMINATION OF THORACIC GAS VOLUME IN CHRONIC OBSTRUCTIVE PULMONARY-DISEASE
复制标题
DOI：
10.1164/arrd.1983.128.1.54
复制
发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
MARTIN, JG
中科院分区：
文献类型：
--
作者：
SHORE, SA;HUK, O;MARTIN, JG
本文研究了3例正常受试者和10例慢性阻塞性肺疾病（COPD）患者的胸廓体积描记仪测量胸廓气体体积与闭塞时喘气频率的关系。通过口压（. delta . pm）和食道压（. delta . pes）的变化得出总肺活量，以反映肺泡压（分别为TLCm和TLCes）的变化。正常受试者的TLCm和tlce随喘气频率的增加而略有下降；TLCm与tlce （TLCm - tlce）的差异较小，且不随频率变化。在患者中，tlce也略有下降，但与正常受试者相比，TLCm随着频率的增加而增加。在低频（小于1hz）， TLCm-TLCes平均为0.14 .+-。0.09 l（平均值+-）。SE)，与0无显著差异。TLCm - tlce随频率增加而增加，平均为1.49 .+-。频率在2.5和3hz之间的0.40 l。在所有频率测试中，脸颊支持减少，但没有消除TLCm和tlce之间的误差。在低频，都是。delta。Pm和delta。pe与体积的变化是同相的。在更高的频率下，体积的变化导致Pm的变化，它们之间的相位角增加到近20度。1例；Pes的变化与体积的相关系更为密切。在慢性阻塞性肺病患者中，只有当喘息频率较低（小于1hz）时，容积描记仪测定绝对肺容量才有效；在较高的喘气频率下，肺泡压力向口腔的传递可能不完全，导致TLC的人为增加。
Dependence of the plethysmographic measurement of thoracic gas volume on the frequency of panting during occlusion was studied in 3 normal subjects and in 10 patients with chronic obstructive pulmonary disease (COPD). Total lung capacity was derived using changes in both mouth (.DELTA.Pm) and esophageal (.DELTA.Pes) pressure to reflect changes in alveolar pressure (TLCm and TLCes, respectively). In the normal subjects, both TLCm and TLCes decreased slightly with increasing frequency of panting; the difference between TLCm and TLCes (TLCm - TLCes) was small and did not vary with frequency. In the patients, TLCes also decreased slightly, but, in contrast to the normal subjects, TLCm increased with increasing frequency. At low frequencies (less than 1 Hz), TLCm-TLCes averaged 0.14 .+-. 0.09 l (mean .+-. SE) and was not significantly different from 0. TLCm - TLCes increased with frequency, averaging 1.49 .+-. 0.40 l at frequencies between 2.5 and 3 Hz. At all frequencies tested, cheek support reduced but did not abolish the error between TLCm and TLCes. At low frequencies, both .DELTA.Pm and .DELTA.Pes were in phase with changes in volume. At higher frequencies, changes in volume led changes in Pm, the phase angle between them increasing to almost 20.degree. in 1 patient; changes in Pes remained much more closely in phase with volume. In patients with COPD, the plethysmographic determination of absolute lung volume is valid only when the frequency of panting is low (less than 1 Hz); at higher panting frequencies, transmission of alveolar pressure to the mouth may be incomplete and result in artifactual increases in TLC.