Effects of alkyl substituents on chiral separation of N-arylthiazolin-2-(thi)-one atropisomers on tris (p-methylbenzoyl)cellulose beads and cellulose triacetate: Lipophilicity aspects
Effects of alkyl substituents on chiral separation of N-arylthiazolin-2-(thi)-one atropisomers on tris (p-methylbenzoyl)cellulose beads and cellulose triacetate: Lipophilicity aspects
复制标题
烷基取代基对三（对甲基苯甲酰）纤维素珠和三乙酸纤维素上 N-芳基噻唑啉-2-(thi)-one 阻转异构体手性分离的影响：亲脂性方面
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
C. Popescu
中科院分区：
文献类型：
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作者：
C. Roussel;C. Popescu
The determination of lipophilicity of the title compounds allowed treatment of the data for chiral separation (capacity factors) on CTA and CTPB according to these parameters. A linear correlation between In k′(+) and log k′w was found on both CTA and CTPB, as far as the substituents are situated in the plane of the aryl ring or the heterocycle. This correlation with a nonchiral descriptor allows treatment of capacity factors for (−)-enantiomers as deviations from the lipophilicity line or derived parallels. It results in a clear description of the molecular area affecting enantioselectivity. Application to larger alkyl derivatives shows that the effect of the substituent should be treated on a basis of attractive effect in the case of CTA and on the basis of attractive and repulsive effects for CTPB. © 1994 Wiley-Liss, Inc.
