Antioxidant activity of natural flavonoids is governed by number and location of their aromatic hydroxyl groups
Antioxidant activity of natural flavonoids is governed by number and location of their aromatic hydroxyl groups
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DOI：
10.1016/0009-3084(96)02523-6
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发表时间：
1996-03-29
影响因子：
3.4
通讯作者：
Wang, J
中科院分区：
文献类型：
--
作者：
Chen, ZY;Chan, PT;Wang, J
我们研究了五种天然黄酮类化合物在菜籽油、乳剂和大鼠红细胞膜中的抗氧化活性。在加热至105摄氏度的芥花油中，杨梅素最有效地减弱了脂质氧化，其次是槲皮素、桑色素和山奈酚。当含有芥花油的乳液在54 ℃下孵育时，槲皮素对脂质氧化的保护作用最强，其次是山萘酚、杨梅素和桑色素，其等级依次降低。芹菜素在芥花油或乳剂中均未表现出抗氧化活性。在所测试的黄酮类化合物中，槲皮素对大鼠红细胞膜自由基链反应的猝灭效果最好。这些黄酮类化合物的抗氧化性受体系、疏水性等多因素的影响。以及芳族羟基的总数和位置。我们的结论是，杨梅素是一种有效的抗氧化剂在菜籽油，而槲皮素是一种有效的保护剂，防止脂质氧化的细胞膜。
We studied antioxidant activity of five natural flavonoids in canola oil, an emulsion, and rat red blood cell membrane. In the canola oil heated at 105 degrees C, myricetin most effectively attenuated lipid oxidation, followed by quercetin, morin and kaempferol in a decreasing order. When the emulsion containing canola oil was incubated at 54 degrees C, quercetin was most protective against lipid oxidation, followed by kaempferol, myricetin and morin in a decreasing rank. Apigenin demonstrated no antioxidant activity in either the canola oil or the emulsion. Of the flavonoids tested, quercetin was the best in quenching free radical chain reaction in rat red blood cell membrane. The antioxidative characteristics of these flavonoids was determined by multiple factors including the system used, the hydrophobicity. and the total number and the location of aromatic hydroxyl groups. We conclude that myricetin is an effective antioxidant in canola oil, while quercetin is an effective protector against lipid oxidation in the cell membrane.