Prognostic and immunological role of Fam20C in pan-cancer.
Prognostic and immunological role of Fam20C in pan-cancer.
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Fam20C 在泛癌中的预后和免疫学作用
DOI：
10.1042/bsr20201920
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发表时间：
2021-01-29
影响因子：
4
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Liu X;Zhan Y;Xu W;Liu X;Geng Y;Liu L;Da J;Wang J;Zhang X;Jin H;Liu Z;Guo S;Zhang B;Li Y
摘要 背景：具有序列相似性的 20 成员 C (Fam20C) 激酶家族在病理生理过程中发挥着重要作用，负责大部分分泌的磷酸化蛋白质组，包括与肿瘤细胞迁移相关的底物。然而，目前尚不清楚 Fam20C 是否在癌症中发挥作用。在这里，我们的目的是分析 Fam20C 在泛癌中的表达和预后价值，并深入了解 Fam20C 与免疫浸润之间的关联。方法：我们通过 ONCOMINE、TIMER（肿瘤免疫估计资源）、PrognoScan、GEPIA（基因表达谱交互分析）和 Kaplan-Meier Plotter 数据库分析了泛癌中 Fam20C 表达模式以及 Fam20C 表达水平与预后之间的关联。之后，应用GEPIA和TIMER数据库研究不同癌症类型，特别是BLCA（膀胱尿路上皮癌）、LGG（脑低级别胶质瘤）和STAD（胃腺癌）中Fam20C表达与免疫浸润之间的关系。结果：与邻近正常组织相比，Fam20C 在多种癌症中广泛表达。总的来说，Fam20C 在泛癌中表现出有害作用，它与 BLCA、LGG 和 STAD 患者的不良生存率呈正相关。具体而言，根据 TCGA（癌症基因组图谱）数据库，Fam20C 的高表达水平与 STAD 患者队列中 T2-T4 期和 N0-N2 期的较差预后值相关。此外，Fam20C 表达与免疫浸润呈正相关，包括 BLCA、LGG 和 STAD 中的 CD4+ T 细胞、巨噬细胞、中性粒细胞和树突状细胞以及其他多种免疫细胞。结论：Fam20C 可能作为泛癌的一种有前景的预后生物标志物，并与免疫浸润呈正相关。
Abstract Background: The family with sequence similarity 20-member C (Fam20C) kinase plays important roles in physiopathological process and is responsible for majority of the secreted phosphoproteome, including substrates associated with tumor cell migration. However, it remains unclear whether Fam20C plays a role in cancers. Here, we aimed to analyze the expression and prognostic value of Fam20C in pan-cancer and to gain insights into the association between Fam20C and immune infiltration. Methods: We analyzed Fam20C expression patterns and the associations between Fam20C expression levels and prognosis in pan-cancer via the ONCOMINE, TIMER (Tumor Immune Estimation Resource), PrognoScan, GEPIA (Gene Expression Profiling Interactive Analysis), and Kaplan–Meier Plotter databases. After that, GEPIA and TIMER databases were applied to investigate the relations between Fam20C expression and immune infiltration across different cancer types, especially BLCA (bladder urothelial carcinoma), LGG (brain lower grade glioma), and STAD (stomach adenocarcinoma). Results: Compared with adjacent normal tissues, Fam20C was widely expressed across many cancers. In general, Fam20C showed a detrimental role in pan-cancer, it was positively associated with poor survival of BLCA, LGG, and STAD patients. Specifically, based on TCGA (The Cancer Genome Atlas) database, a high expression level of Fam20C was associated with worse prognostic value in stages T2–T4 and stages N0–N2 in the cohort of STAD patients. Moreover, Fam20C expression had positive associations with immune infiltration, including CD4+ T cells, macrophages, neutrophils, and dendritic cells, and other diverse immune cells in BLCA, LGG, and STAD. Conclusion: Fam20C may serve as a promising prognostic biomarker in pan-cancer and has positive associations with immune infiltrates.