Imaging Findings and Clinicopathological Correlation of Breast Cancer in Women under 40 Years Old
Imaging Findings and Clinicopathological Correlation of Breast Cancer in Women under 40 Years Old
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DOI：
10.5152/ejbh.2019.4606
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发表时间：
2019-07-01
影响因子：
1.6
通讯作者：
Uner, Aysegul
中科院分区：
文献类型：
--
作者：
Durhan, Gamze;Azizova, Aynur;Uner, Aysegul
目的：本研究的目的是评估40岁以下乳腺癌患者的临床、影像学和组织病理学特征。材料和方法：本研究包括131例年龄在40岁以下，经病理诊断为乳腺癌的患者。结果：本组病例中绝大多数可从临床症状，尤其是可触及的肿块（76.3%）中发现，而CT、MRI、MRI、MRI、MRI等检查均未发现。最常见的肿瘤组织学类型为浸润性导管癌，64.8%的肿瘤为高级别肿瘤。主要特征是边界不规则（92.4%），微分叶状成角轮廓（43.5%），内部回声不均匀（80.9%）超声检查，并存在肿块（41.2%）和可疑的微钙化（40.2%）的钼靶摄影。MRI表现为肿块强化（66.7%），动态曲线为2 ~ 3型（92.6%）。结论：40岁以下女性乳腺癌多表现为可触及肿块，且根据组织学分级可表现出不同的影像学表现。超声检查是诊断年轻女性乳腺癌的主要方式，但乳房X线摄影和磁共振成像可以帮助诊断和评估疾病的程度。
Objective: The aim of this study was to evaluate the clinical, imaging and histopathological features of breast cancer in patients aged under 40 years of age. The relationship between radiological characteristics and histopathological features was also investigated.Materials and Methods: The study included 131 patients aged under 40 years, diagnosed pathologically with breast cancer. A retrospective evaluation was made of the imaging and clinicopathological findings and the relationship between pathological and imaging findings was investigated.Results: Most of the cancers were detected from clinical symptoms, especially a palpable mass (76.3%). The most common histological type of tumor was invasive ductal carcinoma and 64.8% of the tumors were high grade tumors. The predominant features were irregular borders (92.4%), microlobulated-angulated contours (43.5%), hypo-homogeneous internal echogenicity (80.9%) on ultrasonography, and the presence of a mass (41.2%) and suspicious microcalcifications (40.2%) on mammography. Magnetic resonance imaging commonly showed mass enhancement (66.7%) with type 2 or 3 dynamic curve (92.6%). High-grade tumors were associated with posterior acoustic enhancement (p: 0.03) while low-grade tumors presented with spiculated margins more than high grade tumors (p: 0.04).Conclusion: Breast cancer in women aged under 40 years usually presents with a self-detected palpable mass and can show different imaging findings according to the histological grade. Ultrasonography is the main modality for the diagnosis of breast cancer in young women, but mammography and magnetic resonance imaging can help in both diagnosis and evaluation of the extent of disease.