Cellular immunity to mumps virus in young adults 21 years after measles-mumps-rubella vaccination
Cellular immunity to mumps virus in young adults 21 years after measles-mumps-rubella vaccination
复制标题
DOI：
10.1086/521029
复制
发表时间：
2007-09-15
影响因子：
6.4
通讯作者：
Davidkin, Irja
中科院分区：
文献类型：
--
作者：
Jokinen, Sari;Osterlund, Pamela;Davidkin, Irja
背景麻疹-腮腺炎-风疹（MMR）疫苗接种在几个国家降低了麻疹、腮腺炎和风疹病毒感染的发病率。然而，在没有地方性感染的情况下，MMR疫苗诱导的免疫力的持续性仍然未知。对50名在儿童早期接种过两次MMR疫苗并在首次接种后随访21年的个体（A组）进行了对腮腺炎病毒的细胞免疫和不道德免疫的持续性研究。对11例腮腺炎病毒自然获得性免疫者（B组）进行了比较研究。在72%的疫苗中可检测到抗腮腺炎病毒IgG抗体（滴度>= 230）。在98%的A组受试者（平均值+/- SD SI，26 +/- 30 [范围，0.5-252]）和100%的B组受试者（平均值+/-SD SI，22 - 27 [范围，5-123]）中观察到腮腺炎抗原特异性淋巴组织增生反应（定义为刺激指数[SI] ≥ 3）。在A组和B组中均检测到73%的受试者产生了显著的腮腺炎抗原特异性干扰素-γ，在A组和B组中分别检测到40%和36%的受试者产生了白细胞介素-10。所有目前血清阴性的疫苗接种者（n = 14）腮腺炎抗原特异性淋巴细胞增殖反应，只有1血清阳性的疫苗接种者（n = 36）是缺乏可检测的细胞免疫。结果表明，疫苗诱导的抗腮腺炎病毒细胞免疫具有很长的持续性。
Background. Measles-mumps-rubella (MMR) vaccination has decreased the incidence of measles, Mumps, and rubella virus infections in several countries. However, the persistence of MMR vaccine-induced immunity in the absence of endemic infection has remained unknown.Methods. The persistence of cellular and Immoral immunity to mumps virus was studied in 50 individuals (group A) who had been vaccinated twice with MMR vaccine during early childhood and were followed up for 21 years after their first vaccination. Eleven individuals (group B) with naturally acquired immunity to mumps virus were studied for comparison.Results. Anti-mumps virus IgG antibodies were detectable (titer >= 230) in 72% of the vaccinces. A mumps antigen-specific lymphoproliferative response (defined as a stimulatory index [SI] >= 3) was observed in 98% of group A subjects (mean +/- SD SI, 26 +/- 30 [range, 0.5-252]) and in 100% of group B subjects (mean +/- SD SI, 22 27 [range, 5-123]). Significant mumps antigen-specific interferon-gamma production was detected in 73% of subjects in both groups A and B, and interleukin-10 production was detected in 40% and 36% of group A and B subjects, respectively.Conclusions. All presently seronegative vaccinees (n = 14) had mumps antigen-specific lymphoproliferative responses, and only I of the seropositive vaccinees (n = 36) was devoid of detectable cellular immunity. The results suggest a very long persistence of vaccine-induced anti-mumps virus cellular immunity.