SOCS, inflammation, and cancer.
SOCS, inflammation, and cancer.
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DOI：
10.4161/jkst.24053
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发表时间：
2013-07-01
期刊：
影响因子：
--
通讯作者：
Yoshimura A
中科院分区：
文献类型：
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作者：
Inagaki-Ohara K;Kondo T;Ito M;Yoshimura A
由细胞因子和激素引起的信号转导途径已被证明调节发育的不同阶段。细胞因子信号转导抑制因子（SOCS）蛋白是JAK-STAT信号通路介导的细胞因子信号转导的负反馈调节因子。特别是，SOCS 1和SOCS 3是JAK的有效抑制剂，可以在炎症以及癌症的发展和进展中发挥关键作用。据报道，SOCS 1和SOCS 3在癌细胞中的异常表达与来自细胞因子受体、Toll样受体（TLR）和激素受体的信号失调相关，导致恶性肿瘤。本文就SOCS 1和SOCS 3在肿瘤发生发展中的作用作一综述。此外，将讨论SOCS作为治疗靶点和诊断辅助手段的潜力。
Signal transduction pathways elicited by cytokines and hormones have been shown to regulate distinct stages of development. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of cytokine signaling mediated by the JAK-STAT signaling pathway. In particular, SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and progression of cancers. Abnormal expression of SOCS1 and SOCS3 in cancer cells has been reported in human carcinoma associated with dysregulation of signals from cytokine receptors, Toll-like receptors (TLRs), and hormone receptors, resulting in malignancies. In this review, we focus on the role of SOCS1 and SOCS3 in cancer development. In addition, the potential of SOCS as a therapeutic target and diagnostic aid will be discussed.