Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia.
Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia.
复制标题
Narp 基因敲除小鼠对新奇事物表现出正常的反应性，但从恐惧症中恢复的能力减弱。
DOI：
10.1016/j.bbr.2013.10.001
复制
发表时间：
2013
影响因子：
2.7
通讯作者：
Reti,IrvingM
中科院分区：
文献类型：
--
作者：
Blouin,AshleyM;Lee,JongahJ;Tao,Bo;Smith,DaniR;Johnson,AlexanderW;Baraban,JayM;Reti,IrvingM
Narp基因敲除(KO)小鼠表现出认知不灵活和成瘾行为，这与对新刺激的异常反应有关。为了评估对新奇事物的反应性，我们测试了Narp KO和野生型(WT)小鼠的新恐惧症程序。Narp KO和WT小鼠在最初接触一种新口味时都显示出类似的摄入量减少，但Narp KO小鼠在随后接触这种新口味时并不像WT小鼠那样增加摄入量。因此，Narp KO小鼠没有对新奇事物的异常反应，但在适应行为以反映刺激的更新价值方面存在缺陷。
Narp knockout (KO) mice demonstrate cognitive inflexibility and addictive behavior, which are associated with abnormal reactivity to a novel stimulus. To assess reactivity to novelty, we tested Narp KO and wild-type (WT) mice on a neophobia procedure. Both Narp KO and WT mice showed a similar decrease in consumption upon initial exposure to a novel flavor, but Narp KO mice did not increase consumption with subsequent exposures to the novel flavor like the WT mice. Therefore, Narp KO mice do not have abnormal reactivity to novelty but show deficits in adapting behavior to reflect the updated value of a stimulus.