Genetic analysis reveals the complex structure of HIV-1 transmission within defined risk groups
Genetic analysis reveals the complex structure of HIV-1 transmission within defined risk groups
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DOI：
10.1073/pnas.0407534102
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发表时间：
2005-03-22
影响因子：
11.1
通讯作者：
Pybus, OG
中科院分区：
文献类型：
--
作者：
Húe, S;Pillay, D;Pybus, OG
我们通过使用统计学方法，从采样的基因序列数据推断病原体的群体历史，探索了HIV-1亚型B在英国的流行史。来自英国的HIV-1 pol基因序列的系统发育分析显示，至少有六条大的传播链，表明在男男性行为者中存在遗传变异，但在流行病学上是同质的。通过基于聚结剂的分析，我们发现这些链是通过在20世纪80年代早期至中期将B亚型菌株单独引入英国而产生的。在最初的指数增长期之后，传播速度在1990年代初普遍放缓，这更可能与行为改变有关，而不是与高效抗逆转录病毒治疗导致的传染性降低有关。我们的研究结果提供了深入了解HIV-1流行病的复杂性，在制定艾滋病毒监测和预防措施时必须考虑到这一点。
We explored the epidemic history of HIV-1 subtype B in the United Kingdom by using statistical methods that infer the population history of pathogens from sampled gene sequence data. Phylogenetic analysis of HIV-1 pol gene sequences from Britain showed at least six large transmission chains, indicating a genetically variable, but epidemiologically homogeneous, epidemic among men having sex with men. Through coalescent-based analysis, we showed that these chains arose through separate introductions of subtype B strains into the United Kingdom in the early to mid-1980s. After an initial period of exponential growth, the rate of spread generally slowed in the early 1990s, which is more likely to correlate with behavior change than with reduced infectiousness resulting from highly active antiretroviral therapy. Our results provide insights into the complexity of HIV-1 epidemics that must be considered when developing HIV monitoring and prevention initiatives.