Regulation of protein H expression in M1 serotype isolates of Streptococcus pyogenes.
Regulation of protein H expression in M1 serotype isolates of Streptococcus pyogenes.
复制标题
化脓性链球菌 M1 血清型分离株中蛋白 H 表达的调节。
DOI：
10.1016/s0378-1097(02)01184-9
复制
发表时间：
2003
影响因子：
2.1
通讯作者：
Boyle,MichaelDP
中科院分区：
文献类型：
--
作者：
Smith,TaraC;Sledjeski,DarrenD;Boyle,MichaelDP
Protein H is an immunoglobulin-binding protein expressed by certain M1 serotypes ofStreptococcus pyogenes. In a recent study of invasive group A isolates, it was found that none of the 16 M1 serotype isolates analyzed expressed protein H on their surface despite the presence of the protein H gene (sph) in approximately one-third of the isolates. Selection of stable protein H-expressing variants could be achieved by infection ofprtH+non-expressing strains into a mouse skin and recovering bacteria from the spleen. This effect was independent of the transcription regulator Mga, since a similar effect was noted in anmga−mutant. Thus, host passage ofS. pyogenescan lead to stable high level expression of Protein H.
