Genetic analysis of Gv1, a gene controlling transcription of endogenous murine polytropic proviruses
Genetic analysis of Gv1, a gene controlling transcription of endogenous murine polytropic proviruses
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DOI：
10.1128/jvi.73.10.8227-8234.1999
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发表时间：
1999-10-01
影响因子：
5.4
通讯作者：
Stoye, JP
中科院分区：
文献类型：
--
作者：
Oliver, PL;Stoye, JP
Gv1是协调调节多种鼠白血病病毒相关内源原病毒序列表达的遗传位点。已经开发出一种用于 Gv1 遗传分型的定量核酸酶保护测定法。使用该测定法表明Gv1控制多向性内源性原病毒的转录，但不控制修饰的多向性内源性原病毒的转录。使用遗传技术的组合来绘制 Gv1 的图谱；这些分析表明，Gv1 距离小鼠 13 号染色体着丝粒末端约 37 厘摩。
Gv1 is a genetic locus that coordinately regulates the expression of multiple murine leukemia virus-related endogenous proviral sequences. A quantitative nuclease protection assay for typing Gv1 inheritance has been developed. Use of this assay demonstrates that Gv1 controls transcription of polytropic but not of modified polytropic endogenous proviruses. A combination of genetic techniques were used to map Gv1; these analyses demonstrate that Gv1 lies approximately 37 centimorgans from the centromeric end of mouse chromosome 13.