Correlation of GAP-43 immunoreactivity with subpopulations of chromaffin cells in rat adrenal medulla.
Correlation of GAP-43 immunoreactivity with subpopulations of chromaffin cells in rat adrenal medulla.
复制标题
GAP-43 免疫反应性与大鼠肾上腺髓质中嗜铬细胞亚群的相关性。
DOI：
10.1016/0304-3940(93)90552-v
复制
发表时间：
1993
影响因子：
2.5
通讯作者：
Schmidt,RE
中科院分区：
文献类型：
--
作者：
Dorsey,DA;Schmidt,RE
神经生长相关蛋白(GAP-43)在胚胎生长和轴突再生过程中广泛表达，被认为与成年动物的突触可塑性有关。与交感神经节中仅有突触前的GAP-43免疫反应模式相反，GAP-43对成年大鼠肾上腺髓质嗜铬细胞体的去甲肾上腺素能亚群进行了强烈和选择性的标记，这种模式一直伴随着肾上腺去神经支配。含有神经肽Y和苯乙醇胺-N-甲基转移酶免疫反应的相邻肾上腺素能岛不表达GAP-43。在老年和糖尿病大鼠的肾上腺髓质中，GAP-43的免疫组织化学外观没有定性的变化，在这种情况下，交感肾上腺轴被认为是功能失调的。
The neuronal growth-associated protein (GAP-43) is widely expressed during embryonic growth and axonal regeneration and has been thought to contribute to synaptic plasticity in adult animals. In contrast to the exclusively presynaptic pattern of GAP-43 immunoreactivity in sympathetic ganglia, GAP-43 intensely and selectively labeled the noradrenergic subpopulation of adult rat adrenal medullary chromaffin cell bodies, a pattern which persisted with adrenal denervation. Adjacent adrenergic islands containing neuropeptide Y and phenylethanolamine-N-methyl transferase immunoreactivity failed to express GAP-43. The immunohistochemical appearance of GAP-43 was qualitatively unchanged in the adrenal medulla of aged and diabetic rats, conditions in which the sympathoadrenal axis is thought to be dysfunctional.