The many faces of the copper metabolism protein MURRI/COMMDI
The many faces of the copper metabolism protein MURRI/COMMDI
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DOI：
10.1093/jhered/esi110
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发表时间：
2005-11-01
影响因子：
3.1
通讯作者：
Wijmenga, C
中科院分区：
文献类型：
--
作者：
De Bie, P;van de Sluis, B;Wijmenga, C
铜是一种重要的过渡金属，但过量是有毒的；因此，需要严格调节其代谢。铜的调节缺陷可导致以铜缺乏或铜过量为特征的各种疾病。最近，我们发现COMMD1（以前的MURR1）基因是犬铜中毒的缺陷基因。COMMD1的分子功能尚不清楚，但通过鉴定与COMMD1相互作用的蛋白质，在鉴定COMMD1参与的细胞过程方面取得了重大进展。本文综述了COMMD1在铜稳态、钠转运和nf - κ B信号通路中的调节作用。我们概述了COMMD1发挥这些新发现的功能的可能机制。
Copper is an essential transition metal but is toxic in excess; therefore, its metabolism needs to be tightly regulated. Defects in the regulation of copper can lead to various disorders characterized by copper deficiency or copper excess. Recently, we characterized the COMMD1 (previously MURR1) gene as the defective gene in canine copper toxicosis. The molecular functions of COMMD1 remain unknown, but significant progress has been made in identifying the cellular processes in which COMMD1 participates, through the identification of proteins interacting with COMMD1. This review discusses how COMMD1 functions as a regulator of not only copper homeostasis but also sodium transport and the NF-kappa B signaling pathway. We outline the possible mechanisms through which COMMD1 exerts these newly identified functions.