Traumatic Acid Reduces Oxidative Stress and Enhances Collagen Biosynthesis in Cultured Human Skin Fibroblasts.
Traumatic Acid Reduces Oxidative Stress and Enhances Collagen Biosynthesis in Cultured Human Skin Fibroblasts.
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DOI：
10.1007/s11745-016-4174-5
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发表时间：
2016-09
期刊：
影响因子：
1.9
通讯作者：
Czerpak, Romuald
中科院分区：
文献类型：
--
作者：
Jablonska-Trypuc, Agata;Pankiewicz, Walentyn;Czerpak, Romuald
关键词：
创伤酸（TA）是一种植物激素（细胞分裂素），其化学结构属于脂肪酸衍生物。从菜豆（Phaseolus vulgaris）中分离得到。TA活性及其对人体细胞和生物体的影响以前没有研究过。本研究的目的是研究TA对胶原蛋白含量和基本氧化应激参数的影响，如抗氧化酶活性，还原型谷胱甘肽，巯基含量，和脂质过氧化在生理条件下。结果表明，TA对测试参数有刺激作用。TA可减少膜磷脂过氧化反应，并对活性氧的产生具有保护作用。它还增加蛋白质和胶原蛋白的生物合成及其分泌到培养基中。目前的研究结果表明，TA在体外成纤维细胞中表现出多重和复杂的活性。TA具有与不饱和脂肪酸相似的活性，对胶原蛋白的合成具有抗氧化和促进作用。它是一种潜在的强效药物，可用于治疗与氧化应激和胶原蛋白生物合成障碍有关的许多皮肤疾病。
Traumatic acid (TA) is a plant hormone (cytokinin) that in terms of chemical structure belongs to the group of fatty acids derivatives. It was isolated from Phaseolus vulgaris. TA activity and its influence on human cells and organism has not previously been the subject of research. The aim of this study was to examine the effects of TA on collagen content and basic oxidative stress parameters, such as antioxidative enzyme activity, reduced glutathione, thiol group content, and lipid peroxidation in physiological conditions. The results show a stimulatory effect of TA on tested parameters. TA caused a decrease in membrane phospholipid peroxidation and exhibited protective properties against ROS production. It also increases protein and collagen biosynthesis and its secretion into the culture medium. The present findings reveal that TA exhibits multiple and complex activity in fibroblast cells in vitro. TA, with its activity similar to unsaturated fatty acids, shows antioxidant and stimulatory effects on collagen biosynthesis. It is a potentially powerful agent with applications in the treatment of many skin diseases connected with oxidative stress and collagen biosynthesis disorders.
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