Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia
Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia
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DOI：
10.1016/j.fertnstert.2006.08.109
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发表时间：
2007-05-01
影响因子：
6.7
通讯作者：
Anderson, Deborah J.
中科院分区：
文献类型：
--
作者：
Bezold, Guntram;Politch, Joseph A.;Anderson, Deborah J.
目的：确定无症状男性不育患者精液中导致性传播感染（STI）的病原体的患病率，以及伴或不伴白细胞精子症（LCS）的患者的性传播感染（STI）、炎症标志物和其他精液变量之间的相关性。设计：回顾性对照研究。132例有LCS，109例无LCS。干预：无。主要结果测量：性病病原体的DNA（人乳头瘤病毒[HPV]、巨细胞病毒[CMV]、单纯疱疹病毒[HSV]、人疱疹病毒6型[HHV-6]、EB病毒[EBV]、B型肝炎病毒[HBV]和沙眼衣原体[CT]），常规精液参数，结果：45/241例患者检出STI病原体DNA（18.7%）的样本（CMV，8.7%; HPV，4.5%; HHV-6，3.7%; HSV，3.7%; CT，2.5%; EBV，0.4%;和HBV，0%），LCS和非LCS组之间的患病率没有差异。精液中STI病原体的DNA与精子浓度、活动精子浓度、精子总数和中性α-葡萄糖苷酶浓度的降低相关，而LCS与精子总数、正常形态百分比和果糖浓度的降低相关。在无症状男性不育患者的精液中检测到STI病原体DNA的比例很高，并且与精液质量差有关。应加强对亚临床生殖道感染的诊断和治疗。
Objective: To determine the prevalence of pathogens that cause sexually transmitted infections (STIs) in semen from asymptomatic male infertility patients with and without leukocytospermia (LCS), and associations between STIs, inflammatory markers, and other semen variables.Design: Retrospective, controlled study.Setting: Academic Medical Center.Patient(s): Two hundred and forty-one male infertility patients undergoing routine semen analysis: 132 with LCS, and 109 without LCS.Intervention(s): None.Main Outcome Measure(s): The DNA from STI pathogens (human papillomavirus [HPV], cytomegalovirus [CMV], herpes simplex virus [HSV], human herpesvirus type 6 [HHV-6], Epstein-Barr virus [EBV], hepatitis B virus [HBV], and Chlamydia trachomatis [CT]), routine semen parameters, and markers of accessory gland and epididymal function and inflammation.Result(s): The DNA from STI pathogens was detected in 45/241 (18.7%) of the samples (CMV, 8.7%; HPV, 4.5%; HHV-6, 3.7%; HSV, 3.7%; CT, 2.5%; EBV, 0.4%; and HBV, 0%), with no difference in prevalence between the LCS and non-LCS groups. The DNA of STI pathogens in semen was associated with a decrease in sperm concentration, motile sperm concentration, total sperm count, and neutral a-glucosidase concentration, whereas LCS was associated with a decrease in total sperm count, percent normal forms, and fructose concentration.Conclusion(s): The DNA of STI pathogens was detected in semen from a high percentage of asymptomatic male infertility patients, and was associated with poor semen quality. Efforts to diagnose and treat subclinical genital-tract infections should be intensified.