Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2.
Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2.
复制标题
动脉氧分压可减少大鼠肝细胞培养物中静脉周围葡萄糖激酶的胰岛素依赖性诱导：H2O2 模拟动脉氧分压。
DOI：
10.1042/bj3210017
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
K. Jungermann
中科院分区：
文献类型：
--
作者：
T. Kietzmann;U. Roth;Stefanie Freimann;K. Jungermann
肝葡萄糖激酶（GK）主要位于静脉周围区。GK mRNA的诱导最大静脉氧分压（pO2）下，只有一半最大动脉pO2下的胰岛素。氯化钴和去铁胺模拟静脉pO2和增强胰岛素依赖性诱导GK mRNA动脉pO2。H2O2模拟动脉pO2和降低胰岛素诱导的GK mRNA静脉pO2下的动脉水平较低。因此，在肝脏中的带状O2梯度似乎有GK基因的异质性表达的关键作用。
Liver glucokinase (GK) is localized predominantly in the perivenous zone. GK mRNA was induced by insulin maximally under venous O2 partial pressure (pO2) and only half-maximally under arterial pO2. CoCl2 and desferrioxamine mimicked venous pO2 and enhanced the insulin-dependent induction of GK mRNA under arterial pO2. H2O2 mimicked arterial pO2 and reduced insulin-induced GK mRNA under venous pO2 to the lower arterial levels. Thus the zonal O2 gradient in liver seems to have a key role in the heterogenous expression of the GK gene.