SLOW-OSCILLATORY TRANSCRANIAL DIRECT CURRENT STIMULATION CAN INDUCE BIDIRECTIONAL SHIFTS IN MOTOR CORTICAL EXCITABILITY IN AWAKE HUMANS
SLOW-OSCILLATORY TRANSCRANIAL DIRECT CURRENT STIMULATION CAN INDUCE BIDIRECTIONAL SHIFTS IN MOTOR CORTICAL EXCITABILITY IN AWAKE HUMANS
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DOI：
10.1016/j.neuroscience.2010.01.019
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发表时间：
2010-04-14
期刊：
影响因子：
3.3
通讯作者：
Siebner, H. R.
中科院分区：
文献类型：
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作者：
Groppa, S.;Bergmann, T. O.;Siebner, H. R.
持续经颅直接刺激（c-tDCS）一手运动手区（M1(hand)）可以根据tDCS的极性诱导运动皮质兴奋性的双向变化。最近，频率为0.75 Hz的阳极慢振荡刺激已被证明可以增强睡眠时的固有慢振荡和清醒时的θ振荡。为了将这种新型刺激纳入现有的tDCS文献中，我们旨在表征慢振荡刺激（so-tDCS）对M1（HAND）兴奋性的后效，并将其与c-tDCS的后效进行比较。在这里，我们发现0.8 Hz的so-tDCS也可以在清醒期间诱导皮质脊髓兴奋性的持续变化。实验1。在10个健康清醒的个体中，我们分别在不同的日子对左M1（HAND）应用c-tDCS或so-tDCS。每次tDCS持续10分钟。运动诱发电位（MEPs）的测量证实了之前的研究结果，即0.75 mA（最大电流密度0.0625 mA/cm2）的阳极c-tDCS增强了皮质脊髓的兴奋性，而0.75 mA的阴极c-tDCS则降低了皮质脊髓的兴奋性。c-tDCS后，兴奋性的极性特异性转移持续至少20分钟。在0.75 mA的峰值电流强度下，无论是正极还是正极，tdcs对皮质脊髓兴奋性都没有一致的影响。实验2。在另一组10个人中，将so-tDCS的峰值电流强度提高到1.5 mA（最大电流密度0.125 mA/cm2），以使so-tDCS施加的总电流与实验1中c-tDCS在0.75 mA时施加的电流相匹配。在峰值强度为1.5 mA时，阳极和阴极so-tDCS产生的皮质脊髓兴奋性的双向变化与实验1中0.75 mA时c-tDCS所观察到的后效相当。结果表明，如果tDCS过程中施加的电流总量相匹配，so-tDCS可以以与c-tDCS相似的方式诱导皮质脊髓兴奋性的双向变化。(c) 2010 ibro。Elsevier Ltd.出版。版权所有。
Constant transcranial direct stimulation (c-tDCS) of the primary motor hand area (M1(HAND)) can induce bidirectional shifts in motor cortical excitability depending on the polarity of tDCS. Recently, anodal slow oscillation stimulation at a frequency of 0.75 Hz has been shown to augment intrinsic slow oscillations during sleep and theta oscillations during wakefulness. To embed this new type of stimulation into the existing tDCS literature, we aimed to characterize the after effects of slowly oscillating stimulation (so-tDCS) on M1(HAND) excitability and to compare them to those of c-tDCS. Here we show that so-tDCS at 0.8 Hz can also induce lasting changes in corticospinal excitability during wakefulness. Experiment 1. In 10 healthy awake individuals, we applied c-tDCS or so-tDCS to left M1(HAND) on separate days. Each tDCS protocol lasted for 10 min. Measurements of motor evoked potentials (MEPs) confirmed previous work showing that anodal c-tDCS at an intensity of 0.75 mA (maximal current density 0.0625 mA/cm2) enhanced corticospinal excitability, while cathodal c-tDCS at 0.75 mA reduced it. The polarity-specific shifts in excitability persisted for at least 20 min after c-tDCS. Using a peak current intensity of 0.75 mA, neither anodal nor cathodal so-tDCS had consistent effects on corticospinal excitability. Experiment 2. In a separate group of ten individuals, peak current intensity of so-tDCS was raised to 1.5 mA (maximal current density 0.125 mA/cm2) to match the total amount of current applied with so-tDCS to the amount of current that had been applied with c-tDCS at 0.75 mA in Experiment 1. At peak intensity of 1.5 mA, anodal and cathodal so-tDCS produced bidirectional changes in corticospinal excitability comparable to the after effects that had been observed after c-tDCS at 0.75 mA in Experiment 1. The results show that so-tDCS can induce bidirectional shifts in corticospinal excitability in a similar fashion as c-tDCS if the total amount of applied current during the tDCS session is matched. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.