Experimental WHV infection of woodchucks: an animal model of hepadnavirus-induced liver cancer.
Experimental WHV infection of woodchucks: an animal model of hepadnavirus-induced liver cancer.
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土拨鼠的实验性 WHV 感染：嗜肝DNA病毒诱发肝癌的动物模型。
DOI：
10.1007/bf02779926
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Gerin,JL
中科院分区：
文献类型：
--
作者：
Gerin,JL
土拨鼠肝炎病毒（WHV）属于嗜肝DNA病毒科，在病毒结构、遗传组成和复制机制等方面与乙型肝炎病毒（HBV）密切相关。土拨鼠的自然感染与慢性肝病和原发性肝细胞癌（HCC）有关。1980年，一项旨在将土拨鼠作为嗜肝DNA病毒诱导疾病的实验动物模型的共同努力开始了。实验研究已经确定：（1）慢性WHV携带作为感染的结果是暴露年龄，病毒剂量和可能的病毒株的函数。与人类一样，与年轻成年人相比，新生儿感染的动物发生慢性抗原血症的几率很高。(2)WHV导致土拨鼠原发性肝细胞癌（HCC）。百分之百的实验诱导慢性WHsAg携带者在三年内发展为HCC;在同一实验室环境中出生和饲养的同期未感染对照动物中没有发生HCC。实验性WHV感染导致土拨鼠肝脏疾病的可预测过程使其成为研究嗜肝DNA病毒自然史和开发有效预防和治疗策略的理想模型。
Woodchuck hepatitis virus (WHV), a member of the Hepadnaviridae, is closely related to HBV in its virus structure, genetic organization and mechanism of replication. Natural infection of woodchucks is associated with chronic liver disease and primary hepatocellular carcinoma (HCC). A concerted effort to develop the woodchuck as an experimental animal model of hepadnavirus-induced disease was initiated in 1980. The experimental studies have established the following: (1) Chronic WHV carriage as an outcome of infection is a function of age of exposure, virus dose and, possibly, virus strain. As in humans, animals infected as newborns develop chronic antigenemia at high rates compared to young adults. (2) WHV causes primary hepatocellular carcinoma (HCC) in woodchucks. Hundred percent of experimentally-induced chronic WHsAg carriers developed HCC within three years; no HCC has occurred in concurrent uninfected control animals born and held in the same laboratory environment. The predictable course of experimental WHV infection leading to liver disease in woodchucks mades this an ideal model in which to study the natural history of hepadnavirus and to develop effective prophylactic and therapeutec strategies.