Differential regulation of synaptic and extrasynaptic NMDA receptors
Differential regulation of synaptic and extrasynaptic NMDA receptors
复制标题
DOI：
10.1038/nn912
复制
发表时间：
2002-09-01
影响因子：
25
通讯作者：
Raymond, LA
中科院分区：
文献类型：
--
作者：
Li, B;Chen, NS;Raymond, LA
多种过程限制了NMDA(N-甲基-D-天冬氨酸)受体(NMDAR)的活性，以响应激动剂的暴露，包括停滞-重复、持续使用激动剂后峰电流的下降，，。在这里，我们报道了钙和酪氨酸磷酸化不同地调节大鼠海马锥体神经元突触和突触外NMDAR介导的电流的下降。
A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown—the decline of peak current with repeated, sustained agonist application,,,. Here we report that calcium and tyrosine phosphorylation differentially regulate rundown of synaptic versus extrasynaptic NMDAR-mediated current in rat hippocampal pyramidal neurons.