Multilevel Twin Models: Geographical Region as a Third Level Variable.

Multilevel Twin Models: Geographical Region as a Third Level Variable.
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DOI:
10.1007/s10519-021-10047-x
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发表时间:
2021-05
期刊:
影响因子:
2.6
通讯作者:
Boomsma DI
Boomsma DI
中科院分区:
医学3区
文献类型:
--
作者:
Tamimy Z;Kevenaar ST;Hottenga JJ;Hunter MD;de Zeeuw EL;Neale MC;van Beijsterveldt CEM;Dolan CV;van Bergen E;Boomsma DI

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经典的孪生模型可以重新参数化为一个等价的多水平模型。多级参数化具有未充分开发的优点,例如可以包含嵌套较低级别的较高级别聚类变量。当没有对这种更高级别的聚类建模时,其方差由公共环境方差分量捕获。在本文中,我们说明了一个3-水平多层次模型的应用,双胞胎数据分析的区域聚集性7岁儿童的身高在荷兰。我们的研究结果表明,1.8%的儿童身高的表型变异可归因于区域聚类,这是7%的变异解释家庭之间或共同的环境成分。由于区域聚类可能代表祖先,我们还研究了区域的影响后,校正遗传主成分,在一个子样本的参与者与全基因组SNP数据。校正后,区域不再解释高度的变化。我们的研究结果表明,表型变异解释的地区可能代表血统的影响高度。
The classical twin model can be reparametrized as an equivalent multilevel model. The multilevel parameterization has underexplored advantages, such as the possibility to include higher-level clustering variables in which lower levels are nested. When this higher-level clustering is not modeled, its variance is captured by the common environmental variance component. In this paper we illustrate the application of a 3-level multilevel model to twin data by analyzing the regional clustering of 7-year-old children’s height in the Netherlands. Our findings show that 1.8%, of the phenotypic variance in children’s height is attributable to regional clustering, which is 7% of the variance explained by between-family or common environmental components. Since regional clustering may represent ancestry, we also investigate the effect of region after correcting for genetic principal components, in a subsample of participants with genome-wide SNP data. After correction, region no longer explained variation in height. Our results suggest that the phenotypic variance explained by region might represent ancestry effects on height.
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发表时间: 2011-04-01
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