Interleukin-17 in various ocular surface inflammatory diseases.
Interleukin-17 in various ocular surface inflammatory diseases.
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DOI：
10.3346/jkms.2011.26.7.938
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发表时间：
2011-07
影响因子：
4.5
通讯作者：
Lee JH
中科院分区：
文献类型：
--
作者：
Kang MH;Kim MK;Lee HJ;Lee HI;Wee WR;Lee JH
最近发现Th-17细胞或IL-17与葡萄膜炎、巩膜炎和干眼综合征等眼部炎症性疾病有关。我们评估了IL-17是否存在于各种眼表炎症性疾病的泪液中，以及泪液中IL-17的浓度与各种眼表炎性疾病的临床相关性。我们检测了正常人(n=28)和患有眉板腺功能障碍(MGD)、干眼综合征(DES)、Sjögren综合征(SS)、Stevens-Johnson综合征(SJS)、移植物抗宿主病(GVHD)、丝状角膜炎和自身免疫性角膜炎合并类风湿关节炎或系统性红斑狼疮的患者(n=141)泪液中IL-17的浓度。临床上皮病评分基于角膜表面积和结膜荧光素染色。丝状角膜炎、移植物抗宿主病、自身免疫性角膜炎、SS、DES、MGD、SJS患者泪液中IL-17的平均浓度依次高于正常人。在有全身性炎症性疾病的干眼症患者中，泪液IL-17浓度与临床症状积分显著相关，而在无全身性炎症性疾病的干眼症患者中，泪液IL-17浓度与角膜和结膜的临床严重程度无关。泪液IL-17可能只在有全身性炎症的患者中与角膜疾病的严重程度相关。
Recently, the association of Th-17 cells or IL-17 with ocular inflammatory diseases such as uveitis, scleritis and dry eye syndrome was discovered. We assessed whether interleukin (IL)-17 was present in the tears of various ocular surface inflammatory diseases and the tear IL-17 concentrations were clinically correlated with various ocular surface inflammatory diseases. We measured concentrations of IL-17 in tears of normal subjects (n = 28) and patients (n = 141) with meibomian gland dysfunction (MGD), dry eye syndrome (DES), Sjögren syndrome (SS), Stevens-Johnson syndrome (SJS), graft-versus-host disease (GVHD), filamentary keratitis, and autoimmune keratitis associated with rheumatoid arthritis or systemic lupus erythematosus. Clinical epitheliopathy scores were based on the surface area of corneal and conjunctival fluorescein staining. The mean concentrations of IL-17 in tears of patients with filamentary keratitis, GVHD, autoimmune keratitis, SS, DES, MGD, SJS were significantly higher in order than that in normal subjects. Tear IL-17 concentration was significantly correlated with clinical epitheilopathy scores in the patients with systemic inflammatory disease, while tear IL-17 was not correlated with clinical severity of the cornea and conjunctiva in the dry eye patients without any systemic inflammatory disease. Tear IL-17 is likely to correlate clinically with corneal disease severity only in the patients with systemic inflammatory disease.
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影响因子：
5.4
作者：
Gu, Yongpeng;Yang, Jianfei;Ouyang, Xinshou;Liu, Weicheng;Li, Hongxing;Yang, Jianjun;Bromberg, Jonathan;Chen, Shu-Hsia;Mayer, Lloyd;Unkeless, Jay C.;Xiong, Huabao
通讯作者：
Xiong, Huabao
影响因子：
5.6
作者：
Zheng, Xiaofen;Bian, Fang;Ma, Ping;De Paiva, Cintia S.;Stern, Michael;Pflugfelder, Stephen C.;Li, De-Quan
通讯作者：
Li, De-Quan
影响因子：
4.3
作者：
Iclozan, Cristina;Yu, Yu;Liu, Chen;Liang, Yaming;Yi, Tangsheng;Anasetti, Claudio;Yu, Xue-Zhong
通讯作者：
Yu, Xue-Zhong
影响因子：
15.9
作者：
Burlingham, William J.;Love, Robert B.;Willkes, David S.
通讯作者：
Willkes, David S.
影响因子：
6
作者：
Katsifis, Gikas E.;Rekka, Sofia;Wahl, Sharon M.
通讯作者：
Wahl, Sharon M.