Soluble adenylyl cyclase antibody profile as a diagnostic adjunct in the assessment of pigmented lesions.
Soluble adenylyl cyclase antibody profile as a diagnostic adjunct in the assessment of pigmented lesions.
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DOI：
10.1001/archdermatol.2011.338
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发表时间：
2012-03
影响因子：
--
通讯作者：
Zippin, Jonathan H.
中科院分区：
文献类型：
--
作者：
Magro, Cynthia M.;Crowson, A. Neil;Desman, Garrett;Zippin, Jonathan H.
目的：探讨一种新的黑素细胞增殖标志物的应用价值。用一种新型的抗可溶性腺苷环化酶(SAC)的单抗，对各种良性和恶性黑素细胞增殖进行了免疫组织化学染色。美国康奈尔大学威尔医学院皮肤病理学实验室。结果是定性的，不能量化。SAC免疫染色产生了与黑色素瘤发生平行的独特模式。光谱的一极是良性痣，包括特殊部位的不典型痣和复发性痣，表现为明显的点状高尔基染色，而另一极是黑色素瘤，其中许多细胞表现为强烈的盘状核表达模式，常伴有高尔基染色模式的丧失。恶性狼疮性黑色素瘤和肢端狼疮性黑色素瘤表现为最明显的盘状核表达，结节性黑色素瘤表现最少，但胞浆弥漫性表达明显增强。高尔基体表达模式的缺失是恶性黑色素瘤的一个特征。SAC的表达模式是复杂的，但似乎具有歧视性，根据活检病变的性质，具有独特和不同的染色模式。
To investigate the usefulness of a novel marker for melanocytic proliferations. Using a novel monoclonal antibody against soluble adenylyl cyclase (sAC), various benign and malignant melanocytic proliferations were immunostained. Weill Medical College of Cornell University dermatopathology laboratory. The results were qualitative, not quantifiable. The sAC immunostaining produced distinctive patterns that paralleled melanomagenesis. At one pole of the spectrum were benign nevi, including atypical nevi of special sites and recurrent nevi showing a distinct pattern of dotlike Golgi staining, while at the opposite pole was melanoma, in which many cells demonstrated an intense pannuclear expression pattern, often accompanied by loss of the Golgi expression pattern. Melanomas of lentigo maligna and acral lentiginous subtypes exhibited the most striking pannuclear expression, while nodular melanomas showed the least, although with supervening enhanced diffuse cytoplasmic expression. Loss of the Golgi expression pattern was a feature of malignant melanoma. The sAC expression pattern is complex but seems discriminatory, with distinctive and variable staining patterns according to the nature of the lesion biopsied.
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影响因子：
11.2
作者：
Lissitzky, Jean-Claude;Parriaux, Danielle;Verrando, Patrick
通讯作者：
Verrando, Patrick
影响因子：
64.8
作者：
SHEPPARD, JR;KOESTLER, TP;POSTE, G
通讯作者：
POSTE, G
人黑色素瘤细胞中α-核细胞刺激激素的抗炎和抗侵入性作用。
影响因子：
8.8
作者：
Eves, P;Haycock, J;Layton, C;Wagner, M;Kemp, H;Szabo, M;Morandini, R;Ghanem, G;Garcia-Borron, J C;Jimenez-Cervantes, C;Mac Neil, S
通讯作者：
Mac Neil, S
影响因子：
6.4
作者：
SHEPPARD, JR;LESTER, B;POSTE, G
通讯作者：
POSTE, G
影响因子：
4.8
作者：
Calipel, A;Lefevre, G;Mascarelli, F
通讯作者：
Mascarelli, F