Plasma abnormal prothrombin (Des‐γ‐carboxy prothrombin) as a marker of hepatocellular carcinoma
Plasma abnormal prothrombin (Des‐γ‐carboxy prothrombin) as a marker of hepatocellular carcinoma
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血浆异常凝血酶原（Des-γ-羧基凝血酶原）作为肝细胞癌的标志物
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
Tatsuo Sato
中科院分区：
文献类型：
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作者：
S. Fujiyama;T. Morishita;O. Hashiguchi;Tatsuo Sato
Des-γ-羧基凝血酶原[DCP]是一种由维生素K缺乏或拮抗剂-II诱导的蛋白质，也缩写为PIVKA-II，被评估为肝细胞癌（HCC）的血清学标志物。使用抗DCP单克隆抗体，通过酶免疫测定法（E-1023）测定了514例各种疾病患者的血浆水平。在120例HCC患者中，76例（63%）DCP异常水平大于0.1任意单位（Au）/ml，58例（48%）DCP水平大于0.3 Au/ml。当DCP的诊断最低水平为0.3 Au/ml时，几乎消除了HCC的假阳性病例。在一些HCC患者中，手术切除肿瘤后血浆DCP水平正常化。然而，随着疾病的复发，他们又上升了。通过连续和同时测定甲胎蛋白（AFP），DCP在HCC诊断和监测中的灵敏度增加，因为在低AFP产生的HCC患者中更常观察到高DCP水平。血浆DCP水平升高与血清中维生素K浓度低无关。事实上，在许多患者中，维生素K给药仅导致DCP水平适度降低。这些结果表明，DCP是由肝癌细胞合成的。
Des‐γ‐carboxy prothrombin [DCP], a protein induced by vitamin K absence or antagonist‐II and also abbreviated PIVKA‐II, was evaluated as a serologic marker for hepatocellular carcinoma (HCC). Its plasma levels were measured by enzyme immunoassay (E‐1023) using an anti‐DCP monoclonal antibody in 514 patients with various diseases. Of 120 patients with HCC, 76 (63%) had abnormal DCP levels greater than 0.1 arbitrary unit (AU)/ml and 58 (48%) showed levels greater than 0.3 AU/ml. When a diagnostic minimum level of 0.3 AU/ml was applied for DCP, false‐positive cases of HCC were virtually eliminated. In some patients with HCC, plasma DCP levels normalized after surgical resection of the tumor. However, they rose again later with recurrence of the disease. The sensitivity of DCP in the diagnosis and monitoring of HCC was increased by serial and simultaneous determinations of alpha‐fetoprotein (AFP), because high DCP levels were observed more often in low AFP‐producing HCC patients. Elevated plasma DCP levels were not related to low vitamin K concentration in the serum. In fact, in many patients vitamin K administration resulted in only a moderate reduction of DCP levels. These results suggested strongly that DCP was synthesized by the hepatoma cells.
维生素K的功能和代谢。
影响因子：
8.9
作者：
Olson,RE
通讯作者：
Olson,RE