Simple Thermal Pretreatment Strategy to Tune Mechanical and Antifouling Properties of Zwitterionic Hydrogels
Simple Thermal Pretreatment Strategy to Tune Mechanical and Antifouling Properties of Zwitterionic Hydrogels
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调整两性离子水凝胶机械和防污性能的简单热预处理策略
DOI：
10.1021/acs.langmuir.8b01755
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发表时间：
2019
期刊：
影响因子：
3.9
通讯作者：
Wu Jiang
中科院分区：
文献类型：
--
作者：
He Huacheng;Xuan Xuan;Zhang Cuiyun;Song Yi;Chen Shengfu;Gong Xiong;Ren Baiping;Zheng Jie;Wu Jiang
两性离子水凝胶由于其高含水量、三维网络结构和可渗透性而成为一种很有前途的生物材料。然而，两性离子水凝胶的机械性能如何影响其亲水性仍然不清楚。在这项工作中，我们提出了一个简单的，热预处理的方法来制造聚（磺基甜菜碱甲基丙烯酸酯）（pSBMA）水凝胶具有不同的机械性能，可以很容易地通过热预处理时间和交联剂的密度进行调整，以及相关的机械性能与抗静电性能。与未处理的水凝胶相比，所得热处理的pSBMA水凝胶显示出显著增强的机械性能，具有可调的压缩模量和弹性模量。ELISA研究和短期细胞粘附测定的组合也证实了pSBMA水凝胶表现出抵抗蛋白质吸附和细胞粘附的上级疏水特性。进一步的分析显示pSBMA水凝胶的弹性模量和蛋白质吸附之间的线性反演相关性，即，具有较高弹性模量的水凝胶表现出较低的蛋白质吸附（较好的疏水性）。本工作不仅为制备pSBMA水凝胶提供了一种简单的热预处理策略，而且还展示了pSBMA水凝胶的多功能特性，其具有实现一些生物医学应用的巨大潜力。
Zwitterionic hydrogels are promising biomaterials because of their high water content, three-dimensional network structure, and antifouling property. However, it still remains unclear about how mechanical properties of zwitterionic hydrogels affect their antifouling property. In this work, we propose a simple, thermal-pretreatment method to fabricate poly(sulfobetaine methacrylate) (pSBMA) hydrogels with varied mechanical properties that can be readily tuned by thermal pretreatment time and cross-linker density, as well as to correlate their mechanical property with antifouling property. The resulting thermal-treated pSBMA hydrogels show significantly enhanced mechanical properties with tunable compressive modulus and elastic modulus as compared to the untreated hydrogels. A combination of ELISA investigations and short-term cell adhesion assays also confirm that pSBMA hydrogels exhibit superior antifouling properties to resist protein adsorption and cell adhesion. Further analysis shows a linear inversion correlation between elastic modulus and protein adsorption of pSBMA hydrogels, i.e., the hydrogel with the higher elastic modulus exhibits the lower protein adsorption (the better antifouling property). This work not only provides a simple thermal-pretreatment strategy for fabricating pSBMA hydrogels, but also demonstrates multifunctional properties of the pSBMA hydrogels, which possess a great potential to fulfill some biomedical applications.